1lwr

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[[Image:1lwr.png|left|200px]]
 
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{{STRUCTURE_1lwr| PDB=1lwr | SCENE= }}
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==Solution structure of the NCAM fibronectin type III module 2==
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<StructureSection load='1lwr' size='340' side='right'caption='[[1lwr]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lwr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LWR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lwr OCA], [https://pdbe.org/1lwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lwr RCSB], [https://www.ebi.ac.uk/pdbsum/1lwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lwr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCAM1_RAT NCAM1_RAT] This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/1lwr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lwr ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The neural cell adhesion molecule (NCAM) promotes axonal outgrowth, presumably through an interaction with the fibroblast growth factor receptor (FGFR). NCAM also has a little-understood ATPase activity. We here demonstrate for the first time a direct interaction between NCAM (fibronectin type III [F3] modules 1 and 2) and FGFR1 (Ig modules 2 and 3) by surface plasmon resonance (SPR) analysis. The structure of the NCAM F3 module 2 was determined by NMR and the module was shown by NMR to interact with the FGFR1 Ig module 3 and ATP. The NCAM sites binding to FGFR and ATP were found to overlap and ATP was shown by SPR to inhibit the NCAM-FGFR binding, indicating that ATP probably regulates the NCAM-FGFR interaction. Furthermore, we demonstrate that the NCAM module was able to induce activation (phosphorylation) of FGFR and to stimulate neurite outgrowth. In contrast, ATP inhibited neurite outgrowth induced by the module.
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===Solution structure of the NCAM fibronectin type III module 2===
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Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP.,Kiselyov VV, Skladchikova G, Hinsby AM, Jensen PH, Kulahin N, Soroka V, Pedersen N, Tsetlin V, Poulsen FM, Berezin V, Bock E Structure. 2003 Jun;11(6):691-701. PMID:12791257<ref>PMID:12791257</ref>
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{{ABSTRACT_PUBMED_12791257}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1lwr" style="background-color:#fffaf0;"></div>
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[[1lwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LWR OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:012791257</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Berezin, V.]]
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[[Category: Berezin V]]
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[[Category: Bock, E.]]
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[[Category: Bock E]]
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[[Category: Hinsby, A M.]]
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[[Category: Hinsby AM]]
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[[Category: Jensen, P H.]]
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[[Category: Jensen PH]]
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[[Category: Kiselyov, V V.]]
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[[Category: Kiselyov VV]]
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[[Category: Kulahin, N.]]
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[[Category: Kulahin N]]
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[[Category: Pedersen, N.]]
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[[Category: Pedersen N]]
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[[Category: Poulsen, F M.]]
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[[Category: Poulsen FM]]
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[[Category: Skladchikova, G.]]
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[[Category: Skladchikova G]]
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[[Category: Tsetlin, V.]]
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[[Category: Tsetlin V]]
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[[Category: All beta]]
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[[Category: Cell adhesion]]
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[[Category: Fibronectin type iii module]]
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Current revision

Solution structure of the NCAM fibronectin type III module 2

PDB ID 1lwr

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