This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1nsh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1nsh" [edit=sysop:move=sysop])
Current revision (08:55, 22 May 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1nsh.png|left|200px]]
 
-
{{STRUCTURE_1nsh| PDB=1nsh | SCENE= }}
+
==Solution Structure of Rabbit apo-S100A11 (19 models)==
 +
<StructureSection load='1nsh' size='340' side='right'caption='[[1nsh]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1nsh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NSH FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nsh OCA], [https://pdbe.org/1nsh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nsh RCSB], [https://www.ebi.ac.uk/pdbsum/1nsh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nsh ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/S10AB_RABIT S10AB_RABIT] Facilitates the differentiation and the cornification of keratinocytes (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ns/1nsh_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nsh ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
S100A11 is a homodimeric EF-hand calcium binding protein that undergoes a calcium-induced conformational change and interacts with the phospholipid binding protein annexin I to coordinate membrane association. In this work, the solution structure of apo-S100A11 has been determined by NMR spectroscopy to uncover the details of its calcium-induced structural change. Apo-S100A11 forms a tight globular structure having a near antiparallel orientation of helices III and IV in calcium binding site II. Further, helices I and IV, and I and I', form a more closed arrangement than observed in other apo-S100 proteins. This helix arrangement in apo-S100A11 partially buries residues in helices I (P3, E11, A15), III (V55, R58, M59), and IV (A86, C87, S90) and the linker (A45, F46), which are required for interaction with annexin I in the calcium-bound state. In apo-S100A11, this results in a "masked" binding surface that prevents annexin I binding but is uncovered upon calcium binding.
-
===Solution Structure of Rabbit apo-S100A11 (19 models)===
+
Unmasking the annexin I interaction from the structure of Apo-S100A11.,Dempsey AC, Walsh MP, Shaw GS Structure. 2003 Jul;11(7):887-97. PMID:12842051<ref>PMID:12842051</ref>
-
{{ABSTRACT_PUBMED_12842051}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1nsh" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
[[1nsh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NSH OCA].
+
*[[S100 proteins 3D structures|S100 proteins 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:012842051</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
-
[[Category: Dempsey, A C.]]
+
[[Category: Dempsey AC]]
-
[[Category: Shaw, G S.]]
+
[[Category: Shaw GS]]
-
[[Category: Walsh, M P.]]
+
[[Category: Walsh MP]]
-
[[Category: Annexin]]
+
-
[[Category: Calcium-binding protein]]
+
-
[[Category: Ef hand]]
+
-
[[Category: Helix-loop-helix]]
+
-
[[Category: Metal binding protein]]
+
-
[[Category: S100]]
+

Current revision

Solution Structure of Rabbit apo-S100A11 (19 models)

PDB ID 1nsh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nsh"
Personal tools