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1l9l

From Proteopedia

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[[Image:1l9l.png|left|200px]]
 
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{{STRUCTURE_1l9l| PDB=1l9l | SCENE= }}
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==GRANULYSIN FROM HUMAN CYTOLYTIC T LYMPHOCYTES==
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<StructureSection load='1l9l' size='340' side='right'caption='[[1l9l]], [[Resolution|resolution]] 0.92&Aring;' scene=''>
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===GRANULYSIN FROM HUMAN CYTOLYTIC T LYMPHOCYTES===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1l9l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L9L FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12488100}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.92&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l9l OCA], [https://pdbe.org/1l9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l9l RCSB], [https://www.ebi.ac.uk/pdbsum/1l9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l9l ProSAT]</span></td></tr>
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[[1l9l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L9L OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/GNLY_HUMAN GNLY_HUMAN] Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
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<ref group="xtra">PMID:012488100</ref><ref group="xtra">PMID:018754631</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l9/1l9l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l9l ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Anderson, D H.]]
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[[Category: Large Structures]]
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[[Category: Cascio, D.]]
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[[Category: Anderson DH]]
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[[Category: Eisenberg, D.]]
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[[Category: Cascio D]]
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[[Category: Ernst, W.]]
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[[Category: Eisenberg D]]
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[[Category: Krensky, A.]]
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[[Category: Ernst W]]
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[[Category: Modlin, R.]]
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[[Category: Krensky A]]
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[[Category: Sawaya, M R.]]
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[[Category: Modlin R]]
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[[Category: Antimicrobial protein]]
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[[Category: Sawaya MR]]
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[[Category: Granulysin]]
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[[Category: Membrane-lytic]]
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[[Category: Saposin fold]]
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Current revision

GRANULYSIN FROM HUMAN CYTOLYTIC T LYMPHOCYTES

PDB ID 1l9l

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