1nn1
From Proteopedia
(Difference between revisions)
m (Protected "1nn1" [edit=sysop:move=sysop]) |
|||
| (7 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:1nn1.png|left|200px]] | ||
| - | + | ==Crystal structure of human thymidylate kinase with ddTMP and AppNHp== | |
| + | <StructureSection load='1nn1' size='340' side='right'caption='[[1nn1]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1nn1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NN1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2DT:3-DEOXYTHYMIDINE-5-MONOPHOSPHATE'>2DT</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nn1 OCA], [https://pdbe.org/1nn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nn1 RCSB], [https://www.ebi.ac.uk/pdbsum/1nn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nn1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KTHY_HUMAN KTHY_HUMAN] Catalyzes the conversion of dTMP to dTDP. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nn/1nn1_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nn1 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | [[ | + | |
| - | + | ||
| - | + | ||
| - | < | + | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Konrad | + | [[Category: Konrad M]] |
| - | [[Category: Lavie | + | [[Category: Lavie A]] |
| - | [[Category: Meier | + | [[Category: Meier C]] |
| - | [[Category: Monnerjahn | + | [[Category: Monnerjahn M]] |
| - | [[Category: Ostermann | + | [[Category: Ostermann N]] |
| - | [[Category: Segura-Pena | + | [[Category: Segura-Pena D]] |
| - | [[Category: Veit | + | [[Category: Veit T]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of human thymidylate kinase with ddTMP and AppNHp
| |||||||||||
Categories: Homo sapiens | Large Structures | Konrad M | Lavie A | Meier C | Monnerjahn M | Ostermann N | Segura-Pena D | Veit T
