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1l3y

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[[Image:1l3y.png|left|200px]]
 
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{{STRUCTURE_1l3y| PDB=1l3y | SCENE= }}
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==INTEGRIN EGF-LIKE MODULE 3 FROM THE BETA-2 SUBUNIT==
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<StructureSection load='1l3y' size='340' side='right'caption='[[1l3y]]' scene=''>
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===INTEGRIN EGF-LIKE MODULE 3 FROM THE BETA-2 SUBUNIT===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1l3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L3Y FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11896403}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l3y OCA], [https://pdbe.org/1l3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l3y RCSB], [https://www.ebi.ac.uk/pdbsum/1l3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l3y ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1l3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L3Y OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[https://omim.org/entry/116920 116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref> <ref>PMID:1346613</ref> <ref>PMID:1968911</ref> <ref>PMID:1694220</ref> <ref>PMID:1590804</ref> <ref>PMID:1352501</ref> <ref>PMID:1347532</ref> <ref>PMID:7686755</ref> <ref>PMID:9884339</ref> <ref>PMID:20529581</ref> <ref>PMID:20549317</ref>
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==Reference==
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== Function ==
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<ref group="xtra">PMID:011896403</ref><references group="xtra"/>
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[https://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<ref>PMID:18587400</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/1l3y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l3y ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Beglova, N.]]
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[[Category: Large Structures]]
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[[Category: Blacklow, S C.]]
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[[Category: Beglova N]]
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[[Category: Springer, T A.]]
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[[Category: Blacklow SC]]
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[[Category: Takagi, J.]]
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[[Category: Springer TA]]
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[[Category: Beta-2 subunit]]
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[[Category: Takagi J]]
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[[Category: Cell adhesion]]
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[[Category: Cysteine-rich module]]
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[[Category: Egf-like module]]
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[[Category: Integrin]]
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Current revision

INTEGRIN EGF-LIKE MODULE 3 FROM THE BETA-2 SUBUNIT

PDB ID 1l3y

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