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1nbq

From Proteopedia

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[[Image:1nbq.png|left|200px]]
 
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{{STRUCTURE_1nbq| PDB=1nbq | SCENE= }}
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==Crystal Structure of Human Junctional Adhesion Molecule Type 1==
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<StructureSection load='1nbq' size='340' side='right'caption='[[1nbq]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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===Crystal Structure of Human Junctional Adhesion Molecule Type 1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nbq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NBQ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12697893}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nbq OCA], [https://pdbe.org/1nbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nbq RCSB], [https://www.ebi.ac.uk/pdbsum/1nbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nbq ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1nbq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NBQ OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/JAM1_HUMAN JAM1_HUMAN] Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.
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==Reference==
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== Evolutionary Conservation ==
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<ref group="xtra">PMID:012697893</ref><references group="xtra"/>
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nb/1nbq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nbq ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Aurrand-Lions, M.]]
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[[Category: Large Structures]]
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[[Category: Campbell, J A.]]
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[[Category: Aurrand-Lions M]]
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[[Category: Dermody, T S.]]
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[[Category: Campbell JA]]
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[[Category: Forrest, J C.]]
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[[Category: Dermody TS]]
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[[Category: Imhof, B A.]]
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[[Category: Forrest JC]]
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[[Category: Peters, T R.]]
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[[Category: Imhof BA]]
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[[Category: Prota, A E.]]
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[[Category: Peters TR]]
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[[Category: Schelling, P.]]
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[[Category: Prota AE]]
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[[Category: Stehle, T.]]
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[[Category: Schelling P]]
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[[Category: Watson, M J.]]
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[[Category: Stehle T]]
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[[Category: Adhesion molecule]]
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[[Category: Watson MJ]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin superfamily]]
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[[Category: Reovirus receptor]]
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[[Category: Tight junction formation]]
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Current revision

Crystal Structure of Human Junctional Adhesion Molecule Type 1

PDB ID 1nbq

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