1lru

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[[Image:1lru.png|left|200px]]
 
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{{STRUCTURE_1lru| PDB=1lru | SCENE= }}
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==Crystal Structure of E.coli Peptide Deformylase Complexed with Antibiotic Actinonin==
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<StructureSection load='1lru' size='340' side='right'caption='[[1lru]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Crystal Structure of E.coli Peptide Deformylase Complexed with Antibiotic Actinonin===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lru]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LRU FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12126617}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB2:ACTINONIN'>BB2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lru OCA], [https://pdbe.org/1lru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lru RCSB], [https://www.ebi.ac.uk/pdbsum/1lru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lru ProSAT]</span></td></tr>
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[[1lru]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LRU OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/DEF_ECOLI DEF_ECOLI] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
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<ref group="xtra">PMID:012126617</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/1lru_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lru ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Peptide deformylase]]
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[[Category: Large Structures]]
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[[Category: Blanc, V.]]
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[[Category: Blanc V]]
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[[Category: Chevrier, M.]]
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[[Category: Chevrier M]]
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[[Category: Dupuy, A.]]
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[[Category: Dupuy A]]
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[[Category: Famechon, A.]]
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[[Category: Famechon A]]
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[[Category: Giglione, C.]]
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[[Category: Giglione C]]
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[[Category: Gil, P.]]
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[[Category: Gil P]]
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[[Category: Guilloteau, J P.]]
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[[Category: Guilloteau J-P]]
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[[Category: Mathieu, M.]]
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[[Category: Mathieu M]]
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[[Category: Meinnel, T.]]
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[[Category: Meinnel T]]
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[[Category: Mikol, V.]]
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[[Category: Mikol V]]
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[[Category: Actinonin]]
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[[Category: Hydrolase]]
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[[Category: Inhibition]]
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[[Category: Polypeptide deformylase]]
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Current revision

Crystal Structure of E.coli Peptide Deformylase Complexed with Antibiotic Actinonin

PDB ID 1lru

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