1nor

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[[Image:1nor.png|left|200px]]
 
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{{STRUCTURE_1nor| PDB=1nor | SCENE= }}
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==TWO-DIMENSIONAL 1H-NMR STUDY OF THE SPATIAL STRUCTURE OF NEUROTOXIN II FROM NAJA OXIANA==
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<StructureSection load='1nor' size='340' side='right'caption='[[1nor]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nor]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NOR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 19 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nor OCA], [https://pdbe.org/1nor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nor RCSB], [https://www.ebi.ac.uk/pdbsum/1nor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nor ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/3S11_NAJOX 3S11_NAJOX] Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.[UniProtKB:P60775]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/no/1nor_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nor ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The spatial structure of neurotoxin II from the venom of the central Asian cobra Naja naja oxiana was determined by two-dimensional 1H-NMR techniques and computational analysis. Nearly complete proton resonance assignments for 61 amino acid residues have been made using two-dimensional (2D) homonuclear total correlated spectroscopy, 2D homonuclear double-quantum-filtered correlated spectroscopy and 2D homonuclear NOE spectroscopy (NOESY) experiments. The cross-peak volumes in NOESY spectra spin-spin coupling constants of vicinal protons NH-C alpha H and C alpha H-C beta H and the observation of slow deuterium exchange of amide protons were used to define local structure and a set of constraints for distance geometry program DIANA. The average root-mean-square deviations are 53 pm for backbone heavy atoms and 118 pm for all heavy atoms of 19 final neurotoxin II conformations. The spatial structure is characterized by a short double-stranded (residues 1-5 and 13-17) and a triple-stranded (residues 22-30, 33-41 and 50-54) antiparallel beta-sheets.
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===TWO-DIMENSIONAL 1H-NMR STUDY OF THE SPATIAL STRUCTURE OF NEUROTOXIN II FROM NAJA OXIANA===
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Two-dimensional 1H-NMR study of the spatial structure of neurotoxin II from Naja naja oxiana.,Golovanov AP, Lomize AL, Arseniev AS, Utkin YN, Tsetlin VI Eur J Biochem. 1993 May 1;213(3):1213-23. PMID:8504813<ref>PMID:8504813</ref>
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{{ABSTRACT_PUBMED_8504813}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1nor" style="background-color:#fffaf0;"></div>
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[[1nor]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NOR OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:008504813</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Naja oxiana]]
[[Category: Naja oxiana]]
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[[Category: Arseniev, A S.]]
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[[Category: Arseniev AS]]
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[[Category: Golovanov, A P.]]
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[[Category: Golovanov AP]]
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[[Category: Lomize, A L.]]
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[[Category: Lomize AL]]
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[[Category: Tsetlin, V I.]]
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[[Category: Tsetlin VI]]
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[[Category: Utkin, Y N.]]
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[[Category: Utkin YN]]
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[[Category: Neurotoxin]]
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Current revision

TWO-DIMENSIONAL 1H-NMR STUDY OF THE SPATIAL STRUCTURE OF NEUROTOXIN II FROM NAJA OXIANA

PDB ID 1nor

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