1luf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1luf" [edit=sysop:move=sysop])
Current revision (07:36, 14 February 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1luf.png|left|200px]]
 
-
{{STRUCTURE_1luf| PDB=1luf | SCENE= }}
+
==Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation==
 +
<StructureSection load='1luf' size='340' side='right'caption='[[1luf]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1luf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LUF FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1luf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1luf OCA], [https://pdbe.org/1luf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1luf RCSB], [https://www.ebi.ac.uk/pdbsum/1luf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1luf ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MUSK_RAT MUSK_RAT] Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.<ref>PMID:16870737</ref> <ref>PMID:17011580</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lu/1luf_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1luf ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation===
+
==See Also==
-
 
+
*[[Tyrosine kinase receptor 3D structures|Tyrosine kinase receptor 3D structures]]
-
{{ABSTRACT_PUBMED_12220490}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[1luf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUF OCA].
+
</StructureSection>
-
 
+
[[Category: Large Structures]]
-
==Reference==
+
-
<ref group="xtra">PMID:012220490</ref><references group="xtra"/>
+
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Transferase]]
+
[[Category: Becerra M]]
-
[[Category: Becerra, M.]]
+
[[Category: Burden SJ]]
-
[[Category: Burden, S J.]]
+
[[Category: Hubbard SR]]
-
[[Category: Hubbard, S R.]]
+
[[Category: Lu Y]]
-
[[Category: Lu, Y.]]
+
[[Category: Ma Y]]
-
[[Category: Ma, Y.]]
+
[[Category: Neubert TA]]
-
[[Category: Neubert, T A.]]
+
[[Category: Till JH]]
-
[[Category: Till, J H.]]
+
[[Category: Watty A]]
-
[[Category: Watty, A.]]
+
-
[[Category: Mass spectrometry]]
+
-
[[Category: Phosphorylation]]
+
-
[[Category: Signal transduction]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation

PDB ID 1luf

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1luf"
Personal tools