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1n12

From Proteopedia

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[[Image:1n12.png|left|200px]]
 
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{{STRUCTURE_1n12| PDB=1n12 | SCENE= }}
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==Crystal structure of the PapE (N-terminal-deleted) pilus subunit bound to a peptide corresponding to the N-terminal extension of the PapK pilus subunit (residues 1-11) from uropathogenic E. coli==
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<StructureSection load='1n12' size='340' side='right'caption='[[1n12]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
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===Crystal structure of the PapE (N-terminal-deleted) pilus subunit bound to a peptide corresponding to the N-terminal extension of the PapK pilus subunit (residues 1-11) from uropathogenic E. coli===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1n12]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N12 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12437927}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n12 OCA], [https://pdbe.org/1n12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n12 RCSB], [https://www.ebi.ac.uk/pdbsum/1n12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n12 ProSAT]</span></td></tr>
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[[1n12]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N12 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/PAPE_ECOLX PAPE_ECOLX] Repeated PapE subunits make up the thin (2 nm in diameter) tip fibrillum of the pilus. Subunits are arranged in a open helical conformation. Pili with a defective papE gene have low adhesive capacity or none; however, the binding property of the whole cell is not affected. Pili are polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, and enable bacteria to colonize the epithelium of specific host organs.
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<ref group="xtra">PMID:012437927</ref><ref group="xtra">PMID:017511517</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n1/1n12_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n12 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Hultgren, S J.]]
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[[Category: Large Structures]]
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[[Category: Pinkner, J S.]]
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[[Category: Hultgren SJ]]
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[[Category: Sauer, F G.]]
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[[Category: Pinkner JS]]
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[[Category: Waksman, G.]]
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[[Category: Sauer FG]]
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[[Category: Chaperone]]
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[[Category: Waksman G]]
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[[Category: Chaperone priming]]
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[[Category: Donor strand complementation]]
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[[Category: Donor strand exchange]]
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[[Category: Immunoglobulin-like fold]]
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[[Category: Organelle biogenesis]]
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[[Category: Pilus fiber assembly]]
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Current revision

Crystal structure of the PapE (N-terminal-deleted) pilus subunit bound to a peptide corresponding to the N-terminal extension of the PapK pilus subunit (residues 1-11) from uropathogenic E. coli

PDB ID 1n12

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OCA

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