1ng4

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[[Image:1ng4.png|left|200px]]
 
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{{STRUCTURE_1ng4| PDB=1ng4 | SCENE= }}
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==Structure of ThiO (glycine oxidase) from Bacillus subtilis==
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<StructureSection load='1ng4' size='340' side='right'caption='[[1ng4]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===Structure of ThiO (glycine oxidase) from Bacillus subtilis===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ng4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NG4 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12627963}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=PEO:HYDROGEN+PEROXIDE'>PEO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ng4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ng4 OCA], [https://pdbe.org/1ng4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ng4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ng4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ng4 ProSAT]</span></td></tr>
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[[1ng4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NG4 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/GLYOX_BACSU GLYOX_BACSU] Catalyzes the FAD-dependent oxidative deamination of various amines and D-amino acids to yield the corresponding alpha-keto acids, ammonia/amine, and hydrogen peroxide. Oxidizes sarcosine (N-methylglycine), N-ethylglycine and glycine (PubMed:9827558, PubMed:11744710, PubMed:19864430). Can also oxidize the herbicide glyphosate (N-phosphonomethylglycine) (PubMed:19864430). Displays lower activities on D-alanine, D-valine, D-proline and D-methionine (PubMed:9827558, PubMed:11744710). Does not act on L-amino acids and other D-amino acids (PubMed:9827558). Is essential for thiamine biosynthesis since the oxidation of glycine catalyzed by ThiO generates the glycine imine intermediate (dehydroglycine) required for the biosynthesis of the thiazole ring of thiamine pyrophosphate (PubMed:12627963).<ref>PMID:11744710</ref> <ref>PMID:12627963</ref> <ref>PMID:19864430</ref> <ref>PMID:9827558</ref>
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<ref group="xtra">PMID:012627963</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ng/1ng4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ng4 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Augustine, A.]]
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[[Category: Large Structures]]
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[[Category: Begley, T P.]]
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[[Category: Augustine A]]
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[[Category: Dorrestein, P C.]]
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[[Category: Begley TP]]
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[[Category: Ealick, S E.]]
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[[Category: Dorrestein PC]]
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[[Category: Park, J.]]
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[[Category: Ealick SE]]
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[[Category: Settembre, E C.]]
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[[Category: Park J]]
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[[Category: Flavoprotein]]
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[[Category: Settembre EC]]
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[[Category: Oxidase]]
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[[Category: Oxidoreductase]]
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Current revision

Structure of ThiO (glycine oxidase) from Bacillus subtilis

PDB ID 1ng4

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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