1n6j

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[[Image:1n6j.png|left|200px]]
 
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{{STRUCTURE_1n6j| PDB=1n6j | SCENE= }}
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==Structural basis of sequence-specific recruitment of histone deacetylases by Myocyte Enhancer Factor-2==
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<StructureSection load='1n6j' size='340' side='right'caption='[[1n6j]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1n6j]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N6J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n6j OCA], [https://pdbe.org/1n6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n6j RCSB], [https://www.ebi.ac.uk/pdbsum/1n6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n6j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MEF2B_HUMAN MEF2B_HUMAN] Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n6/1n6j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n6j ConSurf].
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<div style="clear:both"></div>
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===Structural basis of sequence-specific recruitment of histone deacetylases by Myocyte Enhancer Factor-2===
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==See Also==
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*[[Myocyte enhancer factor 2|Myocyte enhancer factor 2]]
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{{ABSTRACT_PUBMED_12700764}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1n6j]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6J OCA].
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==Reference==
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<ref group="xtra">PMID:012700764</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, L.]]
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[[Category: Large Structures]]
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[[Category: Han, A.]]
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[[Category: Chen L]]
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[[Category: Liu, J O.]]
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[[Category: Han A]]
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[[Category: Pan, F.]]
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[[Category: Liu JO]]
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[[Category: Stroud, J C.]]
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[[Category: Pan F]]
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[[Category: Youn, H D.]]
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[[Category: Stroud JC]]
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[[Category: Histone deacetylase]]
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[[Category: Youn HD]]
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[[Category: Mads-box]]
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[[Category: Protein-dna complex]]
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[[Category: Transcription-dna complex]]
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Current revision

Structural basis of sequence-specific recruitment of histone deacetylases by Myocyte Enhancer Factor-2

PDB ID 1n6j

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