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1lb6

From Proteopedia

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[[Image:1lb6.png|left|200px]]
 
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{{STRUCTURE_1lb6| PDB=1lb6 | SCENE= }}
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==TRAF6-CD40 Complex==
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<StructureSection load='1lb6' size='340' side='right'caption='[[1lb6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lb6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LB6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb6 OCA], [https://pdbe.org/1lb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lb6 RCSB], [https://www.ebi.ac.uk/pdbsum/1lb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lb6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRAF6_HUMAN TRAF6_HUMAN] E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.<ref>PMID:8837778</ref> <ref>PMID:11057907</ref> <ref>PMID:16378096</ref> <ref>PMID:17135271</ref> <ref>PMID:18093978</ref> <ref>PMID:18758450</ref> <ref>PMID:19675569</ref> <ref>PMID:19713527</ref> <ref>PMID:12140561</ref> <ref>PMID:19465916</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/1lb6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lb6 ConSurf].
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<div style="clear:both"></div>
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===TRAF6-CD40 Complex===
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==See Also==
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*[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]]
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{{ABSTRACT_PUBMED_12140561}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1lb6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB6 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:012140561</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arron, J R.]]
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[[Category: Large Structures]]
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[[Category: Choi, Y.]]
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[[Category: Arron JR]]
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[[Category: Cirilli, M.]]
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[[Category: Choi Y]]
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[[Category: Darnay, B G.]]
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[[Category: Cirilli M]]
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[[Category: Du, K.]]
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[[Category: Darnay BG]]
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[[Category: Dzivenu, O.]]
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[[Category: Du K]]
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[[Category: Kobayashi, T.]]
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[[Category: Dzivenu O]]
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[[Category: Lamothe, B.]]
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[[Category: Kobayashi T]]
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[[Category: Pike, J W.]]
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[[Category: Lamothe B]]
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[[Category: Segal, D.]]
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[[Category: Pike JW]]
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[[Category: Shevde, N K.]]
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[[Category: Segal D]]
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[[Category: Singh, S.]]
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[[Category: Shevde NK]]
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[[Category: Vologodskaia, M.]]
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[[Category: Singh S]]
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[[Category: Wu, H.]]
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[[Category: Vologodskaia M]]
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[[Category: Ye, H.]]
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[[Category: Wu H]]
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[[Category: Yim, M.]]
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[[Category: Ye H]]
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[[Category: Signaling protein]]
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[[Category: Yim M]]
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[[Category: Traf6-cd40 complex]]
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Current revision

TRAF6-CD40 Complex

PDB ID 1lb6

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OCA

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