1lb6
From Proteopedia
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- | [[Image:1lb6.png|left|200px]] | ||
- | + | ==TRAF6-CD40 Complex== | |
+ | <StructureSection load='1lb6' size='340' side='right'caption='[[1lb6]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
+ | == Structural highlights == | ||
+ | <table><tr><td colspan='2'>[[1lb6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LB6 FirstGlance]. <br> | ||
+ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb6 OCA], [https://pdbe.org/1lb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lb6 RCSB], [https://www.ebi.ac.uk/pdbsum/1lb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lb6 ProSAT]</span></td></tr> | ||
+ | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/TRAF6_HUMAN TRAF6_HUMAN] E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.<ref>PMID:8837778</ref> <ref>PMID:11057907</ref> <ref>PMID:16378096</ref> <ref>PMID:17135271</ref> <ref>PMID:18093978</ref> <ref>PMID:18758450</ref> <ref>PMID:19675569</ref> <ref>PMID:19713527</ref> <ref>PMID:12140561</ref> <ref>PMID:19465916</ref> | ||
+ | == Evolutionary Conservation == | ||
+ | [[Image:Consurf_key_small.gif|200px|right]] | ||
+ | Check<jmol> | ||
+ | <jmolCheckbox> | ||
+ | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/1lb6_consurf.spt"</scriptWhenChecked> | ||
+ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
+ | <text>to colour the structure by Evolutionary Conservation</text> | ||
+ | </jmolCheckbox> | ||
+ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lb6 ConSurf]. | ||
+ | <div style="clear:both"></div> | ||
- | == | + | ==See Also== |
- | + | *[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]] | |
- | + | == References == | |
- | + | <references/> | |
- | + | __TOC__ | |
- | [[ | + | </StructureSection> |
- | + | ||
- | == | + | |
- | < | + | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
- | [[Category: Arron | + | [[Category: Large Structures]] |
- | [[Category: Choi | + | [[Category: Arron JR]] |
- | [[Category: Cirilli | + | [[Category: Choi Y]] |
- | [[Category: Darnay | + | [[Category: Cirilli M]] |
- | [[Category: Du | + | [[Category: Darnay BG]] |
- | [[Category: Dzivenu | + | [[Category: Du K]] |
- | [[Category: Kobayashi | + | [[Category: Dzivenu O]] |
- | [[Category: Lamothe | + | [[Category: Kobayashi T]] |
- | [[Category: Pike | + | [[Category: Lamothe B]] |
- | [[Category: Segal | + | [[Category: Pike JW]] |
- | [[Category: Shevde | + | [[Category: Segal D]] |
- | [[Category: Singh | + | [[Category: Shevde NK]] |
- | [[Category: Vologodskaia | + | [[Category: Singh S]] |
- | [[Category: Wu | + | [[Category: Vologodskaia M]] |
- | [[Category: Ye | + | [[Category: Wu H]] |
- | [[Category: Yim | + | [[Category: Ye H]] |
- | + | [[Category: Yim M]] | |
- | + |
Current revision
TRAF6-CD40 Complex
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Categories: Homo sapiens | Large Structures | Arron JR | Choi Y | Cirilli M | Darnay BG | Du K | Dzivenu O | Kobayashi T | Lamothe B | Pike JW | Segal D | Shevde NK | Singh S | Vologodskaia M | Wu H | Ye H | Yim M