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1k3n

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[[Image:1k3n.png|left|200px]]
 
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{{STRUCTURE_1k3n| PDB=1k3n | SCENE= }}
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==NMR Structure of the FHA1 Domain of Rad53 in Complex with a Rad9-derived Phosphothreonine (at T155) Peptide==
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<StructureSection load='1k3n' size='340' side='right'caption='[[1k3n]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1k3n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K3N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k3n OCA], [https://pdbe.org/1k3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k3n RCSB], [https://www.ebi.ac.uk/pdbsum/1k3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k3n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAD53_YEAST RAD53_YEAST] Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. Seems to be involved in the phosphorylation of RPH1.<ref>PMID:8355715</ref> <ref>PMID:7958905</ref> <ref>PMID:10550056</ref> <ref>PMID:11809875</ref> <ref>PMID:15024067</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k3/1k3n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k3n ConSurf].
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<div style="clear:both"></div>
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===NMR Structure of the FHA1 Domain of Rad53 in Complex with a Rad9-derived Phosphothreonine (at T155) Peptide===
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==See Also==
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*[[Protein kinase Spk1|Protein kinase Spk1]]
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{{ABSTRACT_PUBMED_11846567}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1k3n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K3N OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:011846567</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Byeon, I J.L.]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Tsai, M D.]]
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[[Category: Byeon I-JL]]
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[[Category: Yongkiettrakul, S.]]
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[[Category: Tsai M-D]]
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[[Category: Yuan, C.]]
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[[Category: Yongkiettrakul S]]
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[[Category: Zhou, S.]]
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[[Category: Yuan C]]
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[[Category: Fha domain]]
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[[Category: Zhou S]]
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[[Category: Phosphoprotein]]
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[[Category: Phosphothreonine]]
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[[Category: Rad53]]
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[[Category: Rad9]]
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[[Category: Transferase-cell cycle complex]]
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Current revision

NMR Structure of the FHA1 Domain of Rad53 in Complex with a Rad9-derived Phosphothreonine (at T155) Peptide

PDB ID 1k3n

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