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1nea
From Proteopedia
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| - | [[Image:1nea.png|left|200px]] | ||
| - | + | ==THREE-DIMENSIONAL SOLUTION STRUCTURE OF A CURAREMIMETIC TOXIN FROM NAJA NIGRICOLLIS VENOM: A PROTON NMR AND MOLECULAR MODELING STUDY== | |
| - | + | <StructureSection load='1nea' size='340' side='right'caption='[[1nea]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1nea]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_nigricollis Naja nigricollis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NEA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nea OCA], [https://pdbe.org/1nea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nea RCSB], [https://www.ebi.ac.uk/pdbsum/1nea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nea ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1nea]] is a 1 chain structure with sequence from [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/3S11_NAJPA 3S11_NAJPA] Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs) (tested on Torpedo marmorata AChR, Kd=0.07 nM) and with low affinity to neuronal alpha-7/CHRNA7 nAChRs (tested on chimeric receptor, Kd=3 uM) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission (PubMed:9305882). Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.<ref>PMID:9305882</ref> | |
| - | == | + | == Evolutionary Conservation == |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ne/1nea_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nea ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Naja nigricollis]] | [[Category: Naja nigricollis]] | ||
| - | [[Category: Bontems | + | [[Category: Bontems F]] |
| - | [[Category: Gilquin | + | [[Category: Gilquin B]] |
| - | [[Category: Menez | + | [[Category: Menez A]] |
| - | [[Category: Roumestand | + | [[Category: Roumestand C]] |
| - | [[Category: Toma | + | [[Category: Toma F]] |
| - | [[Category: Zinn-Justin | + | [[Category: Zinn-Justin S]] |
| - | + | ||
Current revision
THREE-DIMENSIONAL SOLUTION STRUCTURE OF A CURAREMIMETIC TOXIN FROM NAJA NIGRICOLLIS VENOM: A PROTON NMR AND MOLECULAR MODELING STUDY
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