1l1o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:29, 14 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1l1o.png|left|200px]]
 
-
{{STRUCTURE_1l1o| PDB=1l1o | SCENE= }}
+
==Structure of the human Replication Protein A (RPA) trimerization core==
 +
<StructureSection load='1l1o' size='340' side='right'caption='[[1l1o]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1l1o]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1O FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1o OCA], [https://pdbe.org/1l1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1o RCSB], [https://www.ebi.ac.uk/pdbsum/1l1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1o ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RFA3_HUMAN RFA3_HUMAN] Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/1l1o_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l1o ConSurf].
 +
<div style="clear:both"></div>
-
===Structure of the human Replication Protein A (RPA) trimerization core===
+
==See Also==
-
 
+
*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]]
-
{{ABSTRACT_PUBMED_11927569}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[1l1o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1O OCA].
+
</StructureSection>
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:011927569</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Bochkarev, A.]]
+
[[Category: Large Structures]]
-
[[Category: Bochkareva, E V.]]
+
[[Category: Bochkarev A]]
-
[[Category: Korolev, S.]]
+
[[Category: Bochkareva EV]]
-
[[Category: Lees-Miller, S P.]]
+
[[Category: Korolev S]]
-
[[Category: Dna binding protein]]
+
[[Category: Lees-Miller SP]]
-
[[Category: Eukaryotic ssb]]
+
-
[[Category: Ob-fold]]
+
-
[[Category: Ssdna binding protein]]
+

Current revision

Structure of the human Replication Protein A (RPA) trimerization core

PDB ID 1l1o

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1l1o"
Personal tools