1ktg

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[[Image:1ktg.png|left|200px]]
 
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{{STRUCTURE_1ktg| PDB=1ktg | SCENE= }}
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==Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex==
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<StructureSection load='1ktg' size='340' side='right'caption='[[1ktg]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ktg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KTG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ktg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktg OCA], [https://pdbe.org/1ktg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ktg RCSB], [https://www.ebi.ac.uk/pdbsum/1ktg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ktg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AP4A_CAEEL AP4A_CAEEL] Asymmetrically hydrolyzes Ap4A to yield AMP and ATP.<ref>PMID:11738085</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/1ktg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ktg ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of C. elegans Ap(4)A hydrolase has been determined for the free enzyme and a binary complex at 2.0 A and 1.8 A, respectively. Ap(4)A hydrolase has a key role in regulating the intracellular Ap(4)A levels and hence potentially the cellular response to metabolic stress and/or differentiation and apoptosis via the Ap(3)A/Ap(4)A ratio. The structures reveal that the enzyme has the mixed alpha/beta fold of the Nudix family and also show how the enzyme binds and locates its substrate with respect to the catalytic machinery of the Nudix motif. These results suggest how the enzyme can catalyze the hydrolysis of a range of related dinucleoside tetraphosphate, but not triphosphate, compounds through precise orientation of key elements of the substrate.
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===Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex===
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The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms.,Bailey S, Sedelnikova SE, Blackburn GM, Abdelghany HM, Baker PJ, McLennan AG, Rafferty JB Structure. 2002 Apr;10(4):589-600. PMID:11937063<ref>PMID:11937063</ref>
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{{ABSTRACT_PUBMED_11937063}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1ktg" style="background-color:#fffaf0;"></div>
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[[1ktg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTG OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:011937063</ref><references group="xtra"/>
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Abdelghany, H M.]]
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[[Category: Large Structures]]
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[[Category: Bailey, S.]]
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[[Category: Abdelghany HM]]
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[[Category: Baker, P J.]]
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[[Category: Bailey S]]
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[[Category: Blackburn, G M.]]
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[[Category: Baker PJ]]
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[[Category: McLennan, A G.]]
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[[Category: Blackburn GM]]
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[[Category: Rafferty, J B.]]
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[[Category: McLennan AG]]
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[[Category: Sedelnikova, S E.]]
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[[Category: Rafferty JB]]
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[[Category: Amp]]
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[[Category: Sedelnikova SE]]
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[[Category: Hydrolase]]
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[[Category: Magnesium cluster]]
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[[Category: Nudix]]
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Current revision

Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex

PDB ID 1ktg

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