This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1n4r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1n4r" [edit=sysop:move=sysop])
Current revision (08:45, 10 April 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1n4r.png|left|200px]]
 
-
{{STRUCTURE_1n4r| PDB=1n4r | SCENE= }}
+
==Protein Geranylgeranyltransferase type-I Complexed with a Geranylgeranylated KKKSKTKCVIL Peptide Product==
 +
<StructureSection load='1n4r' size='340' side='right'caption='[[1n4r]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1n4r]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4R FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GER:GERAN-8-YL+GERAN'>GER</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4r OCA], [https://pdbe.org/1n4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4r RCSB], [https://www.ebi.ac.uk/pdbsum/1n4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4r ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n4/1n4r_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4r ConSurf].
 +
<div style="clear:both"></div>
-
===Protein Geranylgeranyltransferase type-I Complexed with a Geranylgeranylated KKKSKTKCVIL Peptide Product===
+
==See Also==
-
 
+
*[[Farnesyltransferase 3D structures|Farnesyltransferase 3D structures]]
-
{{ABSTRACT_PUBMED_14609943}}
+
*[[Geranylgeranyl transferase 3D structures|Geranylgeranyl transferase 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
[[1n4r]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4R OCA].
+
[[Category: Homo sapiens]]
-
 
+
[[Category: Large Structures]]
-
==Reference==
+
-
<ref group="xtra">PMID:014609943</ref><references group="xtra"/>
+
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Beese, L S.]]
+
[[Category: Beese LS]]
-
[[Category: Casey, P J.]]
+
[[Category: Casey PJ]]
-
[[Category: Reid, T S.]]
+
[[Category: Reid TS]]
-
[[Category: Taylor, J S.]]
+
[[Category: Taylor JS]]
-
[[Category: Caax]]
+
-
[[Category: Geranylgeranyl]]
+
-
[[Category: Ggtase]]
+
-
[[Category: Lipid modification]]
+
-
[[Category: Protein geranylgeranyltransferase type-i]]
+
-
[[Category: Protein prenylation]]
+
-
[[Category: Rap2b]]
+
-
[[Category: Transferase]]
+

Current revision

Protein Geranylgeranyltransferase type-I Complexed with a Geranylgeranylated KKKSKTKCVIL Peptide Product

PDB ID 1n4r

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1n4r"
Personal tools