1o0v

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[[Image:1o0v.png|left|200px]]
 
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{{STRUCTURE_1o0v| PDB=1o0v | SCENE= }}
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==The crystal structure of IgE Fc reveals an asymmetrically bent conformation==
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<StructureSection load='1o0v' size='340' side='right'caption='[[1o0v]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1o0v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ls0 1ls0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O0V FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o0v OCA], [https://pdbe.org/1o0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o0v RCSB], [https://www.ebi.ac.uk/pdbsum/1o0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o0v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IGHE_HUMAN IGHE_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o0/1o0v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o0v ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The distinguishing structural feature of immunoglobulin E (IgE), the antibody responsible for allergic hypersensitivity, is the C epsilon 2 domain pair that replaces the hinge region of IgG. The crystal structure of the IgE Fc (constant fragment) at a 2.6-A resolution has revealed these domains. They display a distinctive, disulfide-linked Ig domain interface and are folded back asymmetrically onto the C epsilon 3 and C epsilon 4 domains, which causes an acute bend in the IgE molecule. The structure implies that a substantial conformational change involving C epsilon 2 must accompany binding to the mast cell receptor Fc epsilon RI. This may be the basis of the exceptionally slow dissociation rate of the IgE-Fc epsilon RI complex and, thus, of the ability of IgE to cause persistent allergic sensitization of mast cells.
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===The crystal structure of IgE Fc reveals an asymmetrically bent conformation===
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The crystal structure of IgE Fc reveals an asymmetrically bent conformation.,Wan T, Beavil RL, Fabiane SM, Beavil AJ, Sohi MK, Keown M, Young RJ, Henry AJ, Owens RJ, Gould HJ, Sutton BJ Nat Immunol. 2002 Jul;3(7):681-6. Epub 2002 Jun 17. PMID:12068291<ref>PMID:12068291</ref>
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{{ABSTRACT_PUBMED_12068291}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1o0v" style="background-color:#fffaf0;"></div>
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[[1o0v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ls0 1ls0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0V OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:012068291</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Beavil, A J.]]
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[[Category: Large Structures]]
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[[Category: Beavil, R L.]]
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[[Category: Beavil AJ]]
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[[Category: Fabiane, S M.]]
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[[Category: Beavil RL]]
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[[Category: Gould, H J.]]
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[[Category: Fabiane SM]]
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[[Category: Henry, A J.]]
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[[Category: Gould HJ]]
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[[Category: Keown, M.]]
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[[Category: Henry AJ]]
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[[Category: Owens, R J.]]
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[[Category: Keown M]]
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[[Category: Sohi, M K.]]
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[[Category: Owens RJ]]
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[[Category: Sutton, B J.]]
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[[Category: Sohi MK]]
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[[Category: Wan, T.]]
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[[Category: Sutton BJ]]
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[[Category: Young, R J.]]
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[[Category: Wan T]]
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[[Category: Ige fc]]
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[[Category: Young RJ]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin e]]
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Current revision

The crystal structure of IgE Fc reveals an asymmetrically bent conformation

PDB ID 1o0v

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