1lo6

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[[Image:1lo6.png|left|200px]]
 
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{{STRUCTURE_1lo6| PDB=1lo6 | SCENE= }}
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==Human Kallikrein 6 (hK6) active form with benzamidine inhibitor at 1.56 A resolution==
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<StructureSection load='1lo6' size='340' side='right'caption='[[1lo6]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lo6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LO6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo6 OCA], [https://pdbe.org/1lo6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lo6 RCSB], [https://www.ebi.ac.uk/pdbsum/1lo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KLK6_HUMAN KLK6_HUMAN] Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.<ref>PMID:12878203</ref> <ref>PMID:12928483</ref> <ref>PMID:15557757</ref> <ref>PMID:16987227</ref> <ref>PMID:16321973</ref> <ref>PMID:11983703</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/1lo6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lo6 ConSurf].
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<div style="clear:both"></div>
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===Human Kallikrein 6 (hK6) active form with benzamidine inhibitor at 1.56 A resolution===
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==See Also==
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*[[Kallikrein 3D structures|Kallikrein 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[1lo6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO6 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bernett, M J.]]
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[[Category: Large Structures]]
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[[Category: Blaber, M.]]
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[[Category: Bernett MJ]]
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[[Category: Blaber, S I.]]
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[[Category: Blaber M]]
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[[Category: Dhanarajan, P.]]
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[[Category: Blaber SI]]
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[[Category: Scarisbrick, I A.]]
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[[Category: Dhanarajan P]]
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[[Category: Thompson, S M.]]
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[[Category: Scarisbrick IA]]
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[[Category: Benzamidine]]
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[[Category: Thompson SM]]
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[[Category: Brain serine protease]]
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[[Category: Hk6]]
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[[Category: Human kallikrein 6]]
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[[Category: Hydrolase]]
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[[Category: Kallikrein]]
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[[Category: Msp]]
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[[Category: Myelencephalon specific protease]]
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[[Category: Neurosin]]
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[[Category: Protease]]
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[[Category: Protease m]]
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[[Category: Serine protease]]
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[[Category: Zyme]]
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Current revision

Human Kallikrein 6 (hK6) active form with benzamidine inhibitor at 1.56 A resolution

PDB ID 1lo6

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OCA

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