1s31

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[[Image:1s31.gif|left|200px]]<br /><applet load="1s31" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1s31, resolution 2.704&Aring;" />
 
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'''Crystal Structure Analysis of the human Tub protein (isoform a) spanning residues 289 through 561'''<br />
 
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==Disease==
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==Crystal Structure Analysis of the human Tub protein (isoform a) spanning residues 289 through 561==
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Known disease associated with this structure: Lissencephaly 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602529 602529]]
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<StructureSection load='1s31' size='340' side='right'caption='[[1s31]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1s31]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S31 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S31 FirstGlance]. <br>
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1S31 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PGE:'>PGE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S31 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.704&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s31 OCA], [https://pdbe.org/1s31 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s31 RCSB], [https://www.ebi.ac.uk/pdbsum/1s31 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s31 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TUB_HUMAN TUB_HUMAN] Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s3/1s31_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s31 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Abitbol, M.]]
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[[Category: Abitbol M]]
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[[Category: Basdevant, A.]]
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[[Category: Basdevant A]]
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[[Category: Boutboul, S.]]
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[[Category: Boutboul S]]
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[[Category: Carroll, K J.]]
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[[Category: Carroll KJ]]
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[[Category: Clement, K.]]
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[[Category: Clement K]]
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[[Category: Gomez, C.]]
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[[Category: Gomez C]]
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[[Category: Nandrot, E.]]
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[[Category: Nandrot E]]
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[[Category: Shapiro, L.]]
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[[Category: Shapiro L]]
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[[Category: PGE]]
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[[Category: beta barrel]]
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[[Category: hydrophobic core]]
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[[Category: hydrophobic helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:57:22 2008''
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Current revision

Crystal Structure Analysis of the human Tub protein (isoform a) spanning residues 289 through 561

PDB ID 1s31

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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