1k6g

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1k6g" [edit=sysop:move=sysop])
Current revision (18:45, 29 November 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1k6g.png|left|200px]]
 
-
{{STRUCTURE_1k6g| PDB=1k6g | SCENE= }}
+
==Solution Structure of Conserved AGNN Tetraloops: Insights into Rnt1p RNA Processing==
 +
<StructureSection load='1k6g' size='340' side='right'caption='[[1k6g]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1k6g]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K6G FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6g OCA], [https://pdbe.org/1k6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k6g RCSB], [https://www.ebi.ac.uk/pdbsum/1k6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k6g ProSAT]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Rnt1p, the yeast orthologue of RNase III, cleaves rRNAs, snRNAs and snoRNAs at a stem capped with conserved AGNN tetraloop. Here we show that 9 bp long stems ending with AGAA or AGUC tetraloops bind to Rnt1p and direct specific but sequence-independent RNA cleavage when provided with stems longer than 13 bp. The solution structures of these two tetraloops reveal a common fold for the terminal loop stabilized by non-canonical A-A or A-C pairs and extensive base stacking. The conserved nucleotides are stacked at the 5' side of the loop, exposing their Watson-Crick and Hoogsteen faces for recognition by Rnt1p. These results indicate that yeast RNase III recognizes the fold of a conserved single-stranded tetraloop to direct specific dsRNA cleavage.
-
===Solution Structure of Conserved AGNN Tetraloops: Insights into Rnt1p RNA Processing===
+
Solution structure of conserved AGNN tetraloops: insights into Rnt1p RNA processing.,Lebars I, Lamontagne B, Yoshizawa S, Aboul-Elela S, Fourmy D EMBO J. 2001 Dec 17;20(24):7250-8. PMID:11743001<ref>PMID:11743001</ref>
-
{{ABSTRACT_PUBMED_11743001}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 1k6g" style="background-color:#fffaf0;"></div>
-
[[1k6g]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6G OCA].
+
== References ==
-
 
+
<references/>
-
==Reference==
+
__TOC__
-
<ref group="xtra">PMID:011743001</ref><references group="xtra"/>
+
</StructureSection>
-
[[Category: Elela, S Abou.]]
+
[[Category: Large Structures]]
-
[[Category: Fourmy, D.]]
+
[[Category: Abou Elela S]]
-
[[Category: Lamontagne, B.]]
+
[[Category: Fourmy D]]
-
[[Category: Lebars, I.]]
+
[[Category: Lamontagne B]]
-
[[Category: Yoshizawa, S.]]
+
[[Category: Lebars I]]
-
[[Category: Rna]]
+
[[Category: Yoshizawa S]]
-
[[Category: Rna tetraloop]]
+

Current revision

Solution Structure of Conserved AGNN Tetraloops: Insights into Rnt1p RNA Processing

PDB ID 1k6g

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k6g"
Personal tools