1nb0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:54, 14 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1nb0.png|left|200px]]
 
-
{{STRUCTURE_1nb0| PDB=1nb0 | SCENE= }}
+
==Crystal Structure of Human Riboflavin Kinase==
-
 
+
<StructureSection load='1nb0' size='340' side='right'caption='[[1nb0]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-
===Crystal Structure of Human Riboflavin Kinase===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1nb0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NB0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NB0 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_12623014}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nb0 OCA], [https://pdbe.org/1nb0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nb0 RCSB], [https://www.ebi.ac.uk/pdbsum/1nb0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nb0 ProSAT]</span></td></tr>
-
[[1nb0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NB0 OCA].
+
</table>
-
 
+
== Function ==
-
==Reference==
+
[https://www.uniprot.org/uniprot/RIFK_HUMAN RIFK_HUMAN] Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.
-
<ref group="xtra">PMID:012623014</ref><references group="xtra"/>
+
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nb/1nb0_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nb0 ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Riboflavin kinase]]
+
[[Category: Large Structures]]
-
[[Category: Grishin, N V.]]
+
[[Category: Grishin NV]]
-
[[Category: Karthikeyan, S.]]
+
[[Category: Karthikeyan S]]
-
[[Category: Mseeh, F.]]
+
[[Category: Mseeh F]]
-
[[Category: Osterman, A L.]]
+
[[Category: Osterman AL]]
-
[[Category: Zhang, H.]]
+
[[Category: Zhang H]]
-
[[Category: Zhou, Q.]]
+
[[Category: Zhou Q]]
-
[[Category: Beta barrel]]
+
-
[[Category: Transferase]]
+

Current revision

Crystal Structure of Human Riboflavin Kinase

PDB ID 1nb0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nb0"
Personal tools