1nb0

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[[Image:1nb0.png|left|200px]]
 
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{{STRUCTURE_1nb0| PDB=1nb0 | SCENE= }}
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==Crystal Structure of Human Riboflavin Kinase==
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<StructureSection load='1nb0' size='340' side='right'caption='[[1nb0]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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===Crystal Structure of Human Riboflavin Kinase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nb0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NB0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NB0 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12623014}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nb0 OCA], [https://pdbe.org/1nb0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nb0 RCSB], [https://www.ebi.ac.uk/pdbsum/1nb0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nb0 ProSAT]</span></td></tr>
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[[1nb0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NB0 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/RIFK_HUMAN RIFK_HUMAN] Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.
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<ref group="xtra">PMID:012623014</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nb/1nb0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nb0 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Riboflavin kinase]]
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[[Category: Large Structures]]
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[[Category: Grishin, N V.]]
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[[Category: Grishin NV]]
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[[Category: Karthikeyan, S.]]
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[[Category: Karthikeyan S]]
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[[Category: Mseeh, F.]]
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[[Category: Mseeh F]]
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[[Category: Osterman, A L.]]
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[[Category: Osterman AL]]
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[[Category: Zhang, H.]]
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[[Category: Zhang H]]
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[[Category: Zhou, Q.]]
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[[Category: Zhou Q]]
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[[Category: Beta barrel]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Human Riboflavin Kinase

PDB ID 1nb0

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