1nxi

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[[Image:1nxi.png|left|200px]]
 
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{{STRUCTURE_1nxi| PDB=1nxi | SCENE= }}
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==Solution structure of Vibrio cholerae protein VC0424==
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<StructureSection load='1nxi' size='340' side='right'caption='[[1nxi]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nxi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NXI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nxi OCA], [https://pdbe.org/1nxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nxi RCSB], [https://www.ebi.ac.uk/pdbsum/1nxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nxi ProSAT], [https://www.topsan.org/Proteins/NESGC/1nxi TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9KUU1_VIBCH Q9KUU1_VIBCH] Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity).[HAMAP-Rule:MF_01888]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nx/1nxi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nxi ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of Vibrio cholerae protein VC0424 was determined by NMR spectroscopy. VC0424 belongs to a conserved family of bacterial proteins of unknown function (COG 3076). The structure has an alpha-beta sandwich architecture consisting of two layers: a four-stranded antiparallel beta-sheet and three side-by-side alpha-helices. The secondary structure elements have the order alphabetaalphabetabetaalphabeta along the sequence. This fold is the same as the ferredoxin-like fold, except with an additional long N-terminal helix, making it a variation on this common motif. A cluster of conserved surface residues on the beta-sheet side of the protein forms a pocket that may be important for the biological function of this conserved family of proteins.
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===Solution structure of Vibrio cholerae protein VC0424===
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Solution structure of Vibrio cholerae protein VC0424: a variation of the ferredoxin-like fold.,Ramelot TA, Ni S, Goldsmith-Fischman S, Cort JR, Honig B, Kennedy MA Protein Sci. 2003 Jul;12(7):1556-61. PMID:12824501<ref>PMID:12824501</ref>
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{{ABSTRACT_PUBMED_12824501}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1nxi" style="background-color:#fffaf0;"></div>
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[[1nxi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NXI OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:012824501</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Vibrio cholerae]]
[[Category: Vibrio cholerae]]
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[[Category: Cort, J R.]]
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[[Category: Cort JR]]
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[[Category: Goldsmith-Fischman, S.]]
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[[Category: Goldsmith-Fischman S]]
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[[Category: Honig, B.]]
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[[Category: Honig B]]
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[[Category: Kennedy, M A.]]
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[[Category: Kennedy MA]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Ni S]]
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[[Category: Ni, S.]]
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[[Category: Ramelot TA]]
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[[Category: Ramelot, T A.]]
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[[Category: Ab sandwich]]
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[[Category: Atcc no. 51394d]]
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[[Category: Cog 3076]]
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[[Category: Nesg target op3]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Unknown function]]
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Current revision

Solution structure of Vibrio cholerae protein VC0424

PDB ID 1nxi

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