2m1h
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of a PWWP domain from Trypanosoma brucei== | |
| + | <StructureSection load='2m1h' size='340' side='right'caption='[[2m1h]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2m1h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M1H FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m1h OCA], [https://pdbe.org/2m1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m1h RCSB], [https://www.ebi.ac.uk/pdbsum/2m1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m1h ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q586X9_TRYB2 Q586X9_TRYB2] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | TbTFIIS2-1, one of the two TFIIS homologues of Trypanosome brucei (T. brucei), cooperates with TbTFIIS1 in regulating transcription in T. brcuei. Structurally divergent from other TFIIS homologues from higher organisms, TbTFIIS2-1 contains an additional N-terminal PWWP domain besides other three conserved domains, which may imply potential role of TbTFIIS2-1 in transcription regulation. Here, we determined the solution structure of PWWP domain of TbTFIIS2-1 by NMR spectroscopy, which was the first solution structure of PWWP domain solved in trypanosomatid. In spite of poor sequence similarity between PWWP domains, this domain of TbTFIIS2-1 adopts a conserved 3D-structure, which contains a fi ve-stranded beta-barrel and a C-terminal alpha-helix. Furthermore, we found that TbTFIIS2-1 PWWP domain may be a protein-protein interaction module without the ability of DNA recognition and methyl-group interaction. This article is protected by copyright. All rights reserved. | ||
| - | + | Solution structure of TbTFIIS2-1 PWWP domain from Trypanosoma brucei.,Wang R, Zhang J, Liao S, Tu X Proteins. 2016 Mar 23. doi: 10.1002/prot.25035. PMID:27005948<ref>PMID:27005948</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 2m1h" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Elongation factor 3D structures|Elongation factor 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Trypanosoma brucei]] | ||
| + | [[Category: Fan K]] | ||
| + | [[Category: Liao S]] | ||
| + | [[Category: Tu X]] | ||
| + | [[Category: Wang R]] | ||
| + | [[Category: Zhang J]] | ||
Current revision
Solution structure of a PWWP domain from Trypanosoma brucei
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Categories: Large Structures | Trypanosoma brucei | Fan K | Liao S | Tu X | Wang R | Zhang J
