4i79

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(New page: '''Unreleased structure''' The entry 4i79 is ON HOLD Authors: Xu, C., Tempel, W., Li, Z., He, H., Wernimont, A.K., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Geno...)
Current revision (15:16, 20 September 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4i79 is ON HOLD
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==Crystal structure of human NUP43==
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<StructureSection load='4i79' size='340' side='right'caption='[[4i79]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4i79]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I79 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i79 OCA], [https://pdbe.org/4i79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i79 RCSB], [https://www.ebi.ac.uk/pdbsum/4i79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i79 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NUP43_HUMAN NUP43_HUMAN] Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.<ref>PMID:17363900</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Nuclear pore complexes (NPC) form nuclear pores that cross the nuclear envelope and allow molecules to transport between the nucleus and the cytoplasm. We solved the crystal structure of human Nup43 (hNUP43), an important component in the Nup107 subcomplex of NPC. hNup43 adopts a seven-bladed beta-propeller fold. We confirmed by ITC that neither human Nup37 (hNup37) nor human Nup133 (hNup133) interacts with hNup43. We demonstrated by analytical gel filtration that the human Nup85-Seh1L binary complex recruits hNup43 to form a ternary complex. Based on amino acid sequence analysis, we predicted the hNup85-hSeh1L binding surface of hNup43.
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Authors: Xu, C., Tempel, W., Li, Z., He, H., Wernimont, A.K., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
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Crystal structure of human nuclear pore complex component NUP43.,Xu C, Li Z, He H, Wernimont A, Li Y, Loppnau P, Min J FEBS Lett. 2015 Sep 22. pii: S0014-5793(15)00825-X. doi:, 10.1016/j.febslet.2015.09.008. PMID:26391640<ref>PMID:26391640</ref>
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Description: Crystal structure of human NUP43
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4i79" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Edwards AM]]
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[[Category: He H]]
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[[Category: Li Z]]
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[[Category: Min J]]
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[[Category: Tempel W]]
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[[Category: Wernimont AK]]
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[[Category: Xu C]]

Current revision

Crystal structure of human NUP43

PDB ID 4i79

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