4iao

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(New page: '''Unreleased structure''' The entry 4iao is ON HOLD Authors: Hsu, H.C., Wang, C.L., Wang, M., Yang, N., Chen, Z, Sternglanz, R., Xu, R.M. Description: Crystal structure of Sir-2 C543S...)
Current revision (08:52, 20 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4iao is ON HOLD
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==Crystal structure of Sir2 C543S mutant in complex with SID domain of Sir4==
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<StructureSection load='4iao' size='340' side='right'caption='[[4iao]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4iao]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IAO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.901&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iao OCA], [https://pdbe.org/4iao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iao RCSB], [https://www.ebi.ac.uk/pdbsum/4iao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iao ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SIR2_YEAST SIR2_YEAST] NAD-dependent deacetylase, which participates in a wide range of cellular events including chromosome silencing, chromosome segregation, DNA recombination and the determination of life span. Involved in transcriptional repression of the silent mating-type loci HML and HMR and telomeric silencing via its association with SIR3 and SIR4. Plays a central role in ribosomal DNA (rDNA) silencing via its association with the RENT complex, preventing hyperrecombination, and repressing transcription from foreign promoters, which contributes to extending life span. Probably represses transcription via the formation of heterochromatin structure, which involves the compaction of chromatin fiber into a more condensed form, although this complex in at least one case can still bind euchromatic levels of positive transcription regulators. Although it displays some NAD-dependent histone deacetylase activity on histone H3K9Ac and H3K14Ac and histone H4K16Ac in vitro, such activity is unclear in vivo and may not be essential.<ref>PMID:10619427</ref> <ref>PMID:10693811</ref> <ref>PMID:9278054</ref> <ref>PMID:12923057</ref> <ref>PMID:15274642</ref> <ref>PMID:18086879</ref> <ref>PMID:19220062</ref>
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Authors: Hsu, H.C., Wang, C.L., Wang, M., Yang, N., Chen, Z, Sternglanz, R., Xu, R.M.
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==See Also==
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*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
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Description: Crystal structure of Sir-2 C543S mutant in complex with SID domain of Sir4
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Chen Z]]
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[[Category: Hsu HC]]
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[[Category: Sternglanz R]]
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[[Category: Wang CL]]
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[[Category: Wang M]]
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[[Category: Xu RM]]
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[[Category: Yang N]]

Current revision

Crystal structure of Sir2 C543S mutant in complex with SID domain of Sir4

PDB ID 4iao

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