4f7z

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[[Image:4f7z.png|left|200px]]
 
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{{STRUCTURE_4f7z| PDB=4f7z | SCENE= }}
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==Conformational dynamics of exchange protein directly activated by cAMP==
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<StructureSection load='4f7z' size='340' side='right'caption='[[4f7z]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===Conformational dynamics of exchange protein directly activated by cAMP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4f7z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F7Z FirstGlance]. <br>
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{{ABSTRACT_PUBMED_23189173}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f7z OCA], [https://pdbe.org/4f7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f7z RCSB], [https://www.ebi.ac.uk/pdbsum/4f7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f7z ProSAT]</span></td></tr>
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[[4f7z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F7Z OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RPGF4_MOUSE RPGF4_MOUSE] Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.<ref>PMID:11056535</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Cheng, X.]]
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[[Category: Cheng X]]
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[[Category: Liu, T.]]
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[[Category: Liu T]]
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[[Category: Mei, F C.]]
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[[Category: Mei FC]]
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[[Category: Tsalkova, T N.]]
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[[Category: Tsalkova TN]]
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[[Category: White, M A.]]
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[[Category: White MA]]
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[[Category: Woods, V L.]]
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[[Category: Woods VL]]
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[[Category: Auto-inhibition]]
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[[Category: Cdc25 homology domain]]
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[[Category: Cyclic nucleotide]]
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[[Category: Exchange factor]]
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[[Category: Exocytosis]]
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[[Category: Gef]]
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[[Category: Regulation]]
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Current revision

Conformational dynamics of exchange protein directly activated by cAMP

PDB ID 4f7z

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