4hkf

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[[Image:4hkf.jpg|left|200px]]
 
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{{STRUCTURE_4hkf| PDB=4hkf | SCENE= }}
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==Crystal structure of Danio rerio MEC-17 catalytic domain in complex with acetyl-CoA==
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<StructureSection load='4hkf' size='340' side='right'caption='[[4hkf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HKF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hkf OCA], [https://pdbe.org/4hkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hkf RCSB], [https://www.ebi.ac.uk/pdbsum/4hkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hkf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATAT_DANRE ATAT_DANRE] Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May promote directional cell locomotion and chemotaxis (By similarity). May be required for normal sperm flagellar function (By similarity). May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development. Acetylates alpha-tubulin in neurons, but not in cilia.[HAMAP-Rule:MF_03130]<ref>PMID:20829795</ref>
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===Crystal structure of Danio rerio MEC-17 catalytic domain in complex with acetyl-CoA===
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==See Also==
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*[[Alpha-tubulin N-acetyltransferase 3D structures|Alpha-tubulin N-acetyltransferase 3D structures]]
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*[[Tubulin acetyltransferase|Tubulin acetyltransferase]]
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==About this Structure==
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== References ==
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[[4hkf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKF OCA].
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<references/>
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[[Category: Alpha-tubulin N-acetyltransferase]]
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__TOC__
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</StructureSection>
[[Category: Danio rerio]]
[[Category: Danio rerio]]
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[[Category: Ding, J.]]
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[[Category: Large Structures]]
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[[Category: Li, W.]]
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[[Category: Ding J]]
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[[Category: Sun, B.]]
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[[Category: Li W]]
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[[Category: Xu, S.]]
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[[Category: Sun B]]
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[[Category: Zhang, T.]]
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[[Category: Xu S]]
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[[Category: Zhong, C.]]
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[[Category: Zhang T]]
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[[Category: Acetyl-coa]]
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[[Category: Zhong C]]
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[[Category: Gnat]]
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[[Category: Gnat fold]]
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[[Category: Mec-17]]
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[[Category: Transferase]]
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[[Category: Tubulin acetyltransferase]]
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Current revision

Crystal structure of Danio rerio MEC-17 catalytic domain in complex with acetyl-CoA

PDB ID 4hkf

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