4ey8

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[[Image:4ey8.png|left|200px]]
 
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{{STRUCTURE_4ey8| PDB=4ey8 | SCENE= }}
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==Crystal structure of recombinant human acetylcholinesterase in complex with fasciculin-2==
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<StructureSection load='4ey8' size='340' side='right'caption='[[4ey8]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ey8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EY8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5958&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ey8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ey8 OCA], [https://pdbe.org/4ey8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ey8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ey8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ey8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human acetylcholinesterase (AChE) is a significant target for therapeutic drugs. Here we present high resolution crystal structures of human AChE, alone and in complexes with drug ligands; donepezil, an Alzheimer's disease drug, binds differently to human AChE than it does to Torpedo AChE. These crystals of human AChE provide a more accurate platform for further drug development than previously available.
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===Crystal structure of recombinant human acetylcholinesterase in complex with fasciculin-2===
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Structures of human acetylcholinesterase in complex with pharmacologically important ligands.,Cheung J, Rudolph MJ, Burshteyn F, Cassidy MS, Gary EN, Love J, Franklin MC, Height JJ J Med Chem. 2012 Oct 4. PMID:23035744<ref>PMID:23035744</ref>
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{{ABSTRACT_PUBMED_23035744}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4ey8" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[4ey8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EY8 OCA].
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*[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]]
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[[Category: Acetylcholinesterase]]
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*[[Fasciculin|Fasciculin]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Dendroaspis angusticeps]]
[[Category: Dendroaspis angusticeps]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Burshteyn, F.]]
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[[Category: Large Structures]]
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[[Category: Cassidy, M.]]
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[[Category: Burshteyn F]]
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[[Category: Cheung, J.]]
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[[Category: Cassidy M]]
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[[Category: Franklin, M.]]
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[[Category: Cheung J]]
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[[Category: Gary, E.]]
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[[Category: Franklin M]]
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[[Category: Height, J.]]
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[[Category: Gary E]]
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[[Category: Love, J.]]
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[[Category: Height J]]
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[[Category: Rudolph, M.]]
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[[Category: Love J]]
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[[Category: Acetylcholinesterase]]
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[[Category: Rudolph M]]
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[[Category: Fasciculin 2]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inhibitor]]
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[[Category: Snake venom toxin]]
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Current revision

Crystal structure of recombinant human acetylcholinesterase in complex with fasciculin-2

PDB ID 4ey8

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