4f9b

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[[Image:4f9b.png|left|200px]]
 
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{{STRUCTURE_4f9b| PDB=4f9b | SCENE= }}
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==Human CDC7 kinase in complex with DBF4 and PHA767491==
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<StructureSection load='4f9b' size='340' side='right'caption='[[4f9b]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Human CDC7 kinase in complex with DBF4 and PHA767491===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4f9b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F9B FirstGlance]. <br>
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{{ABSTRACT_PUBMED_23064647}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0SY:2-(PYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE'>0SY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f9b OCA], [https://pdbe.org/4f9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f9b RCSB], [https://www.ebi.ac.uk/pdbsum/4f9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f9b ProSAT]</span></td></tr>
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[[4f9b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F9B OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DBF4A_HUMAN DBF4A_HUMAN] Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.<ref>PMID:10373557</ref> <ref>PMID:10523313</ref> <ref>PMID:17062569</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Cherepanov, P.]]
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[[Category: Cherepanov P]]
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[[Category: Hughes, S.]]
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[[Category: Hughes S]]
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[[Category: Atp-binding]]
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[[Category: Cell cycle]]
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[[Category: Cell division]]
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[[Category: Dbf4-dependent kinase]]
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[[Category: Ddk]]
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[[Category: Mitosis]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphorylation]]
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[[Category: S phase]]
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[[Category: Ser/thr protein kinase]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Zinc-binding]]
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Current revision

Human CDC7 kinase in complex with DBF4 and PHA767491

PDB ID 4f9b

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