1ozn

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[[Image:1ozn.png|left|200px]]
 
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{{STRUCTURE_1ozn| PDB=1ozn | SCENE= }}
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==1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent Recognition Scaffold Mediating Inhibition of Myelination==
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<StructureSection load='1ozn' size='340' side='right'caption='[[1ozn]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
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===1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent Recognition Scaffold Mediating Inhibition of Myelination===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ozn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OZN FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12718853}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.52&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ozn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ozn OCA], [https://pdbe.org/1ozn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ozn RCSB], [https://www.ebi.ac.uk/pdbsum/1ozn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ozn ProSAT]</span></td></tr>
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[[1ozn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZN OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/RTN4R_HUMAN RTN4R_HUMAN] Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity).<ref>PMID:12037567</ref> <ref>PMID:14966521</ref>
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<ref group="xtra">PMID:012718853</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oz/1ozn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ozn ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bazan, J F.]]
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[[Category: Large Structures]]
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[[Category: Garcia, K C.]]
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[[Category: Bazan JF]]
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[[Category: He, X.]]
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[[Category: Garcia KC]]
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[[Category: He, Z.]]
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[[Category: He X]]
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[[Category: McDermott, G.]]
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[[Category: He Z]]
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[[Category: Park, J B.]]
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[[Category: McDermott G]]
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[[Category: Ligand binding]]
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[[Category: Park JB]]
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[[Category: Mad]]
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[[Category: Mag]]
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[[Category: Myelination inhibition]]
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[[Category: Neuronal regeneration]]
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[[Category: Nogo receptor]]
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[[Category: Nogo-66]]
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[[Category: Omgp]]
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[[Category: P75]]
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[[Category: Signal transduction]]
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[[Category: Signaling protein]]
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Current revision

1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent Recognition Scaffold Mediating Inhibition of Myelination

PDB ID 1ozn

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