1osh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:02, 14 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1osh.png|left|200px]]
 
-
{{STRUCTURE_1osh| PDB=1osh | SCENE= }}
+
==A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR==
 +
<StructureSection load='1osh' size='340' side='right'caption='[[1osh]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1osh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OSH FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FEX:METHYL+3-{3-[(CYCLOHEXYLCARBONYL){[4-(DIMETHYLAMINO)BIPHENYL-4-YL]METHYL}AMINO]PHENYL}ACRYLATE'>FEX</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1osh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osh OCA], [https://pdbe.org/1osh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1osh RCSB], [https://www.ebi.ac.uk/pdbsum/1osh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1osh ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/1osh_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1osh ConSurf].
 +
<div style="clear:both"></div>
-
===A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR===
+
==See Also==
-
 
+
*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
-
{{ABSTRACT_PUBMED_12718892}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[1osh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSH OCA].
+
</StructureSection>
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:012718892</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Alvarez, J G.A.]]
+
[[Category: Large Structures]]
-
[[Category: Anisfeld, A M.]]
+
[[Category: Alvarez JGA]]
-
[[Category: Bowman, M E.]]
+
[[Category: Anisfeld AM]]
-
[[Category: Downes, M.]]
+
[[Category: Bowman ME]]
-
[[Category: Edwards, P A.]]
+
[[Category: Downes M]]
-
[[Category: Evans, R M.]]
+
[[Category: Edwards PA]]
-
[[Category: Ferrer, J L.]]
+
[[Category: Evans RM]]
-
[[Category: Hogenesch, J B.]]
+
[[Category: Ferrer J-L]]
-
[[Category: Hughes, R.]]
+
[[Category: Hogenesch JB]]
-
[[Category: Kast-Woelbern, H R.]]
+
[[Category: Hughes R]]
-
[[Category: Nicolaou, K C.]]
+
[[Category: Kast-Woelbern HR]]
-
[[Category: Noel, J P.]]
+
[[Category: Nicolaou KC]]
-
[[Category: Roecker, A J.]]
+
[[Category: Noel JP]]
-
[[Category: Rosenfeld, J M.]]
+
[[Category: Roecker AJ]]
-
[[Category: Verdecia, M A.]]
+
[[Category: Rosenfeld JM]]
-
[[Category: Ligand binding domain]]
+
[[Category: Verdecia MA]]
-
[[Category: Nuclear receptor]]
+
-
[[Category: Transcription]]
+

Current revision

A Chemical, Genetic, and Structural Analysis of the nuclear bile acid receptor FXR

PDB ID 1osh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1osh"
Personal tools