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1o84

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[[Image:1o84.png|left|200px]]
 
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{{STRUCTURE_1o84| PDB=1o84 | SCENE= }}
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==Crystal Structure of Bacteriocin AS-48. N-decyl-beta-D-maltoside Bound.==
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<StructureSection load='1o84' size='340' side='right'caption='[[1o84]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1o84]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O84 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D10:DECANE'>D10</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o84 OCA], [https://pdbe.org/1o84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o84 RCSB], [https://www.ebi.ac.uk/pdbsum/1o84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o84 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q47765_ENTFL Q47765_ENTFL]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The bacteriocin AS-48 is a membrane-interacting peptide, which displays a broad anti-microbial spectrum against Gram-positive and Gram-negative bacteria. The NMR structure of AS-48 at pH 3 has been solved. The analysis of this structure suggests that the mechanism of AS-48 anti-bacterial activity involves the accumulation of positively charged molecules at the membrane surface leading to a disruption of the membrane potential. Here, we report the high-resolution crystal structure of AS-48 and sedimentation equilibrium experiments showing that this bacteriocin is able to adopt different oligomeric structures according to the physicochemical environment. The analysis of these structures suggests a mechanism for molecular function of AS-48 involving a transition from a water-soluble form to a membrane-bound state upon membrane binding.
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===CRYSTAL STRUCTURE OF BACTERIOCIN AS-48. N-DECYL-BETA-D-MALTOSIDE BOUND.===
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Structure of bacteriocin AS-48: from soluble state to membrane bound state.,Sanchez-Barrena MJ, Martinez-Ripoll M, Galvez A, Valdivia E, Maqueda M, Cruz V, Albert A J Mol Biol. 2003 Nov 28;334(3):541-9. PMID:14623193<ref>PMID:14623193</ref>
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{{ABSTRACT_PUBMED_14623193}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1o84" style="background-color:#fffaf0;"></div>
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[[1o84]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O84 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:014623193</ref><references group="xtra"/>
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</StructureSection>
[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
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[[Category: Albert, A.]]
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[[Category: Large Structures]]
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[[Category: Cruz, V.]]
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[[Category: Albert A]]
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[[Category: Galvez, A.]]
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[[Category: Cruz V]]
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[[Category: Maqueda, M.]]
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[[Category: Galvez A]]
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[[Category: Martinez-Ripoll, M.]]
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[[Category: Maqueda M]]
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[[Category: Sanchez-Barrena, M J.]]
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[[Category: Martinez-Ripoll M]]
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[[Category: Valdivia, E.]]
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[[Category: Sanchez-Barrena MJ]]
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[[Category: Antibacterial peptide]]
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[[Category: Valdivia E]]
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[[Category: Bacteriocin]]
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[[Category: Cyclic polypeptide]]
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[[Category: Membrane permeabilization]]
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[[Category: Peptide antibiotic]]
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[[Category: Protein crystallography]]
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[[Category: Protein membrane interaction]]
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Current revision

Crystal Structure of Bacteriocin AS-48. N-decyl-beta-D-maltoside Bound.

PDB ID 1o84

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