1od8

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[[Image:1od8.png|left|200px]]
 
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{{STRUCTURE_1od8| PDB=1od8 | SCENE= }}
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==Xylanase Xyn10A from Streptomyces lividans in complex with xylobio-isofagomine lactam==
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<StructureSection load='1od8' size='340' side='right'caption='[[1od8]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1od8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OD8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XDL:XYLOSE-DERIVED+ISOFAGOMINE+LACTAM'>XDL</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1od8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1od8 OCA], [https://pdbe.org/1od8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1od8 RCSB], [https://www.ebi.ac.uk/pdbsum/1od8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1od8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/XYNA_STRLI XYNA_STRLI] Contributes to hydrolyze hemicellulose, the major component of plant cell-walls. XLNA and XLNB seem to act sequentially on the substrate to yield xylobiose and xylose as carbon sources.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/od/1od8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1od8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The atomic-resolution structure of a xylobiose-derived isofagomine lactam in complex with the xylanase Xyn10A from Streptomyces lividans reveals that the lactam is bound to the enzyme as the amide tautomer, with "reversed" protonation-states for nucleophile and acid-base.
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===XYLANASE XYN10A FROM STREPTOMYCES LIVIDANS IN COMPLEX WITH XYLOBIO-ISOFAGOMINE LACTAM===
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A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer.,Gloster T, Williams SJ, Tarling CA, Roberts S, Dupont C, Jodoin P, Shareck F, Withers SG, Davies GJ Chem Commun (Camb). 2003 Apr 21;(8):944-5. PMID:12744311<ref>PMID:12744311</ref>
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{{ABSTRACT_PUBMED_12744311}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1od8" style="background-color:#fffaf0;"></div>
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[[1od8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OD8 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:012744311</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Endo-1,4-beta-xylanase]]
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[[Category: Large Structures]]
[[Category: Streptomyces lividans]]
[[Category: Streptomyces lividans]]
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[[Category: Davies, G J.]]
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[[Category: Davies GJ]]
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[[Category: Gloster, T M.]]
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[[Category: Gloster TM]]
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[[Category: Roberts, S.]]
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[[Category: Roberts S]]
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[[Category: Glycoside hydrolase family 10]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-lectin complex]]
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[[Category: Hydrolase/lectin]]
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[[Category: Isofagomine lactam]]
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[[Category: Lectin]]
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[[Category: Transition state mimic]]
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[[Category: Xylan degradation]]
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[[Category: Xylanase]]
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Current revision

Xylanase Xyn10A from Streptomyces lividans in complex with xylobio-isofagomine lactam

PDB ID 1od8

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