4hp1

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[[Image:4hp1.png|left|200px]]
 
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{{STRUCTURE_4hp1| PDB=4hp1 | SCENE= }}
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==Crystal structure of Tet3 in complex with a non-CpG dsDNA==
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<StructureSection load='4hp1' size='340' side='right'caption='[[4hp1]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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===Crystal structure of Tet3 in complex with a non-CpG dsDNA===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hp1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HP1 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_23217707}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hp1 OCA], [https://pdbe.org/4hp1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hp1 RCSB], [https://www.ebi.ac.uk/pdbsum/4hp1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hp1 ProSAT]</span></td></tr>
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[[4hp1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_(silurana)_tropicalis Xenopus (silurana) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HP1 OCA].
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</table>
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[[Category: Arrowsmith, C H.]]
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== Function ==
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[[Category: Bian, C.]]
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[https://www.uniprot.org/uniprot/TET3_XENTR TET3_XENTR] Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. Conversion of 5mC into 5hmC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes, including pax6, rax, sox9 and six3. May also contribute to the regulation of target genes in ways that do not require its enzyme activity.<ref>PMID:23217707</ref>
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[[Category: Bountra, C.]]
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== References ==
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[[Category: Chao, X.]]
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<references/>
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[[Category: Edwards, A M.]]
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__TOC__
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[[Category: Min, J.]]
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</StructureSection>
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Large Structures]]
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[[Category: Tempel, W.]]
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[[Category: Xenopus tropicalis]]
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[[Category: Cxxc]]
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[[Category: Arrowsmith CH]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Bian C]]
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[[Category: Dna methylation]]
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[[Category: Bountra C]]
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[[Category: Sgc]]
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[[Category: Chao X]]
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[[Category: Structural genomic]]
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[[Category: Edwards AM]]
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[[Category: Structural genomics consortium]]
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[[Category: Min J]]
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[[Category: Tempel W]]

Current revision

Crystal structure of Tet3 in complex with a non-CpG dsDNA

PDB ID 4hp1

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