4ia3

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'''Unreleased structure'''
 
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The entry 4ia3 is ON HOLD until Paper Publication
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==Diastereotopic and Deuterium Effects in Gemini==
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<StructureSection load='4ia3' size='340' side='right'caption='[[4ia3]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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Authors: Maehr, H., Rochel, N., Suh, N., Uskokovic, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ia3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IA3 FirstGlance]. <br>
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Description: Diastereotopic and Deuterium Effects in Gemini
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BIV:21-NOR-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL,+20-(4-HYDROXY-4-METHYLPENTYL)-,+(1A,3B,5Z,7E)'>BIV</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ia3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ia3 OCA], [https://pdbe.org/4ia3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ia3 RCSB], [https://www.ebi.ac.uk/pdbsum/4ia3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ia3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VDRA_DANRE VDRA_DANRE] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Plays a central role in calcium homeostasis.<ref>PMID:17218092</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Danio rerio]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Maehr H]]
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[[Category: Rochel N]]
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[[Category: Suh N]]
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[[Category: Uskokovic M]]

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Diastereotopic and Deuterium Effects in Gemini

PDB ID 4ia3

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