4iau
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Atomic resolution structure of Geodin, a beta-gamma crystallin from Geodia cydonium== | |
| + | <StructureSection load='4iau' size='340' side='right'caption='[[4iau]], [[Resolution|resolution]] 0.99Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4iau]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geodia_cydonium Geodia cydonium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IAU FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.99Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iau OCA], [https://pdbe.org/4iau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iau RCSB], [https://www.ebi.ac.uk/pdbsum/4iau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iau ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/O18426_GEOCY O18426_GEOCY] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The betagamma-crystallin superfamily includes highly diverse proteins belonging to all of the kingdoms of life. Based on structural topology, these proteins are considered to be evolutionarily related to the long-lived betagamma-crystallins that constitute the vertebrate eye lens. This study reports the crystallographic structure at 0.99 A resolution of the two-domain betagamma-crystallin (geodin) from the sponge Geodia cydonium. This is the most ancient member of the betagamma-crystallin superfamily in metazoans. The X-ray structure shows that the geodin domains adopt the typical betagamma-crystallin fold with a paired Greek-key motif, thus confirming the hypothesis that the crystallin-type scaffold used in the evolution of bacteria and moulds was recruited very early in metazoans. As a significant new structural feature, the sponge protein possesses a unique interdomain interface made up by pairing between the second motif of the first domain and the first motif of the second domain. The atomic resolution also allowed a detailed analysis of the calcium-binding site of the protein. | ||
| - | + | A novel interdomain interface in crystallins: structural characterization of the betagamma-crystallin from Geodia cydonium at 0.99 A resolution.,Vergara A, Grassi M, Sica F, Pizzo E, D'Alessio G, Mazzarella L, Merlino A Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):960-7. doi:, 10.1107/S0907444913003569. Epub 2013 May 2. PMID:23695240<ref>PMID:23695240</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4iau" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Crystallin 3D structures|Crystallin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Geodia cydonium]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Grassi M]] | ||
| + | [[Category: Mazzarella L]] | ||
| + | [[Category: Merlino A]] | ||
| + | [[Category: Sica F]] | ||
| + | [[Category: Vergara A]] | ||
Current revision
Atomic resolution structure of Geodin, a beta-gamma crystallin from Geodia cydonium
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