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1pok

From Proteopedia

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[[Image:1pok.png|left|200px]]
 
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{{STRUCTURE_1pok| PDB=1pok | SCENE= }}
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==Crystal structure of Isoaspartyl Dipeptidase==
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<StructureSection load='1pok' size='340' side='right'caption='[[1pok]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1pok]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1POK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASN:ASPARAGINE'>ASN</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pok OCA], [https://pdbe.org/1pok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pok RCSB], [https://www.ebi.ac.uk/pdbsum/1pok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pok ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IADA_ECOLI IADA_ECOLI] Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. The best substrate for the enzyme reported thus far is iso-Asp-Leu.<ref>PMID:7876157</ref> <ref>PMID:4880759</ref> <ref>PMID:12718528</ref> <ref>PMID:15882050</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/po/1pok_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pok ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of Isoaspartyl Dipeptidase===
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==See Also==
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*[[Isoaspartyl dipeptidase|Isoaspartyl dipeptidase]]
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{{ABSTRACT_PUBMED_12946361}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1pok]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POK OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:012946361</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Bode, W.]]
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[[Category: Large Structures]]
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[[Category: Huber, R.]]
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[[Category: Bode W]]
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[[Category: Jozic, D.]]
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[[Category: Huber R]]
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[[Category: Kaiser, J T.]]
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[[Category: Jozic D]]
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[[Category: Maskos, K.]]
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[[Category: Kaiser JT]]
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[[Category: Hydrolase]]
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[[Category: Maskos K]]

Current revision

Crystal structure of Isoaspartyl Dipeptidase

PDB ID 1pok

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