1p57

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[[Image:1p57.png|left|200px]]
 
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{{STRUCTURE_1p57| PDB=1p57 | SCENE= }}
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==Extracellular domain of human hepsin==
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<StructureSection load='1p57' size='340' side='right'caption='[[1p57]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1p57]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P57 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CR4:2-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}BENZENOLATE'>CR4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p57 OCA], [https://pdbe.org/1p57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p57 RCSB], [https://www.ebi.ac.uk/pdbsum/1p57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p57 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HEPS_HUMAN HEPS_HUMAN] Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL.<ref>PMID:21875933</ref> <ref>PMID:15839837</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p5/1p57_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p57 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hepsin is an integral membrane protein that may participate in cell growth and in maintaining proper cell morphology and is overexpressed in a number of primary tumors. We have determined the 1.75 A resolution structure of the extracellular component of human hepsin. This structure includes a 255-residue trypsin-like serine protease domain and a 109-residue region that forms a novel, poorly conserved, scavenger receptor cysteine-rich (SRCR) domain. The two domains are associated with each other through a single disulfide bond and an extensive network of noncovalent interactions. The structure suggests how the extracellular region of hepsin may be positioned with respect to the plasma membrane.
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===Extracellular domain of human hepsin===
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The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.,Somoza JR, Ho JD, Luong C, Ghate M, Sprengeler PA, Mortara K, Shrader WD, Sperandio D, Chan H, McGrath ME, Katz BA Structure. 2003 Sep;11(9):1123-31. PMID:12962630<ref>PMID:12962630</ref>
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{{ABSTRACT_PUBMED_12962630}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1p57" style="background-color:#fffaf0;"></div>
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[[1p57]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P57 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:012962630</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chan, H.]]
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[[Category: Large Structures]]
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[[Category: Ho, J D.]]
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[[Category: Chan H]]
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[[Category: Katz, B A.]]
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[[Category: Ho JD]]
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[[Category: Luong, C.]]
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[[Category: Katz BA]]
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[[Category: McGrath, M E.]]
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[[Category: Luong C]]
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[[Category: Mortara, K.]]
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[[Category: McGrath ME]]
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[[Category: Shrader, W D.]]
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[[Category: Mortara K]]
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[[Category: Somoza, J R.]]
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[[Category: Shrader WD]]
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[[Category: Sperandio, D.]]
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[[Category: Somoza JR]]
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[[Category: Sprengeler, P A.]]
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[[Category: Sperandio D]]
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[[Category: Hydrolase]]
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[[Category: Sprengeler PA]]
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[[Category: Scavenger receptor cysteine-rich domain]]
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[[Category: Serine protease]]
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[[Category: Srcr]]
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Current revision

Extracellular domain of human hepsin

PDB ID 1p57

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