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1pk1

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[[Image:1pk1.png|left|200px]]
 
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{{STRUCTURE_1pk1| PDB=1pk1 | SCENE= }}
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==Hetero SAM domain structure of Ph and Scm.==
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<StructureSection load='1pk1' size='340' side='right'caption='[[1pk1]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===Hetero SAM domain structure of Ph and Scm.===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1pk1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PK1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PK1 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15905166}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pk1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pk1 OCA], [https://pdbe.org/1pk1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pk1 RCSB], [https://www.ebi.ac.uk/pdbsum/1pk1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pk1 ProSAT]</span></td></tr>
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[[1pk1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PK1 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/PHP_DROME PHP_DROME] Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Plays a role in regulating the expression of other pair-rule genes such as eve, ftz, and H.<ref>PMID:1346609</ref>
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<ref group="xtra">PMID:015905166</ref><ref group="xtra">PMID:010448041</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/1pk1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pk1 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Bowie, J U.]]
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[[Category: Large Structures]]
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[[Category: Cascio, D.]]
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[[Category: Bowie JU]]
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[[Category: Kim, C A.]]
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[[Category: Cascio D]]
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[[Category: Kim, W.]]
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[[Category: Kim CA]]
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[[Category: Sawaya, M R.]]
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[[Category: Kim W]]
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[[Category: Hetero sam domain]]
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[[Category: Sawaya MR]]
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[[Category: Polymer]]
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[[Category: Transcription repression]]
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[[Category: Transcriptional repression]]
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Current revision

Hetero SAM domain structure of Ph and Scm.

PDB ID 1pk1

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