1poz

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[[Image:1poz.png|left|200px]]
 
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{{STRUCTURE_1poz| PDB=1poz | SCENE= }}
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==SOLUTION STRUCTURE OF THE HYALURONAN BINDING DOMAIN OF HUMAN CD44==
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<StructureSection load='1poz' size='340' side='right'caption='[[1poz]]' scene=''>
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===SOLUTION STRUCTURE OF THE HYALURONAN BINDING DOMAIN OF HUMAN CD44===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1poz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1POZ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_14992719}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1poz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1poz OCA], [https://pdbe.org/1poz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1poz RCSB], [https://www.ebi.ac.uk/pdbsum/1poz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1poz ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1poz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POZ OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/CD44_HUMAN CD44_HUMAN] Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/po/1poz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1poz ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[CD44|CD44]]
*[[CD44|CD44]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:014992719</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Banerji, S.]]
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[[Category: Large Structures]]
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[[Category: Blundell, C D.]]
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[[Category: Banerji S]]
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[[Category: Campbell, I D.]]
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[[Category: Blundell CD]]
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[[Category: Day, A J.]]
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[[Category: Campbell ID]]
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[[Category: Jackson, D G.]]
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[[Category: Day AJ]]
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[[Category: Kahmann, J D.]]
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[[Category: Jackson DG]]
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[[Category: Pickford, A R.]]
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[[Category: Kahmann JD]]
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[[Category: Teriete, P.]]
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[[Category: Pickford AR]]
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[[Category: Wright, A J.]]
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[[Category: Teriete P]]
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[[Category: Carbohydrate-binding domain]]
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[[Category: Wright AJ]]
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[[Category: Cell adhesion]]
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[[Category: Glycoprotein]]
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[[Category: Hyaluronan-binding domain]]
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[[Category: Link module]]
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Current revision

SOLUTION STRUCTURE OF THE HYALURONAN BINDING DOMAIN OF HUMAN CD44

PDB ID 1poz

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