1pjc

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[[Image:1pjc.png|left|200px]]
 
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{{STRUCTURE_1pjc| PDB=1pjc | SCENE= }}
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==L-ALANINE DEHYDROGENASE COMPLEXED WITH NAD==
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<StructureSection load='1pjc' size='340' side='right'caption='[[1pjc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1pjc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phormidium_lapideum Phormidium lapideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PJC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjc OCA], [https://pdbe.org/1pjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pjc RCSB], [https://www.ebi.ac.uk/pdbsum/1pjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pjc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O52942_PHOLP O52942_PHOLP]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pj/1pjc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pjc ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of the hexameric L-alanine dehydrogenase from Phormidium lapideum reveals that the subunit is constructed from two domains, each having the common dinucleotide binding fold. Despite there being no sequence similarity, the fold of alanine dehydrogenase is closely related to that of the family of D-2-hydroxyacid dehydrogenases, with a similar location of the active site, suggesting that these enzymes are related by divergent evolution. L-alanine dehydrogenase and the 2-hydroxyacid dehydrogenases also use equivalent functional groups to promote substrate recognition and catalysis. However, they are arranged differently on the enzyme surface, which has the effect of directing opposite faces of the keto acid to the dinucleotide in each case, forcing a change in absolute configuration of the product.
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===L-ALANINE DEHYDROGENASE COMPLEXED WITH NAD===
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Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase.,Baker PJ, Sawa Y, Shibata H, Sedelnikova SE, Rice DW Nat Struct Biol. 1998 Jul;5(7):561-7. PMID:9665169<ref>PMID:9665169</ref>
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{{ABSTRACT_PUBMED_9665169}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1pjc" style="background-color:#fffaf0;"></div>
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[[1pjc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Phormidium_lapideum Phormidium lapideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJC OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:009665169</ref><ref group="xtra">PMID:011178916</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Alanine dehydrogenase]]
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[[Category: Large Structures]]
[[Category: Phormidium lapideum]]
[[Category: Phormidium lapideum]]
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[[Category: Baker, P J.]]
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[[Category: Baker PJ]]
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[[Category: Rice, D W.]]
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[[Category: Rice DW]]
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[[Category: Sawa, Y.]]
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[[Category: Sawa Y]]
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[[Category: Sedelnikova, S E.]]
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[[Category: Sedelnikova SE]]
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[[Category: Shibata, H.]]
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[[Category: Shibata H]]
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[[Category: Nad]]
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[[Category: Oxidoreductase]]
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Current revision

L-ALANINE DEHYDROGENASE COMPLEXED WITH NAD

PDB ID 1pjc

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