1pa7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:28, 13 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1pa7.png|left|200px]]
 
-
{{STRUCTURE_1pa7| PDB=1pa7 | SCENE= }}
+
==Crystal structure of amino-terminal microtubule binding domain of EB1==
 +
<StructureSection load='1pa7' size='340' side='right'caption='[[1pa7]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1pa7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PA7 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pa7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pa7 OCA], [https://pdbe.org/1pa7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pa7 RCSB], [https://www.ebi.ac.uk/pdbsum/1pa7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pa7 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MARE1_HUMAN MARE1_HUMAN] Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.<ref>PMID:12388762</ref> <ref>PMID:21646404</ref> <ref>PMID:16109370</ref> <ref>PMID:19632184</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pa/1pa7_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pa7 ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of amino-terminal microtubule binding domain of EB1===
+
==See Also==
-
 
+
*[[End-binding protein|End-binding protein]]
-
{{ABSTRACT_PUBMED_12857735}}
+
*[[Microtubule-associated protein 3D structures|Microtubule-associated protein 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
[[1pa7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PA7 OCA].
+
__TOC__
-
 
+
</StructureSection>
-
==Reference==
+
-
<ref group="xtra">PMID:012857735</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Hayashi, I.]]
+
[[Category: Large Structures]]
-
[[Category: Ikura, M.]]
+
[[Category: Hayashi I]]
-
[[Category: Ch domain]]
+
[[Category: Ikura M]]
-
[[Category: Structural protein]]
+

Current revision

Crystal structure of amino-terminal microtubule binding domain of EB1

PDB ID 1pa7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pa7"
Personal tools