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1pa0

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[[Image:1pa0.png|left|200px]]
 
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{{STRUCTURE_1pa0| PDB=1pa0 | SCENE= }}
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==CRYSTAL STRUCTURE OF BNSP-7, A LYS49-PHOSPHOLIPASE A2==
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<StructureSection load='1pa0' size='340' side='right'caption='[[1pa0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1pa0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_pauloensis Bothrops pauloensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PA0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pa0 OCA], [https://pdbe.org/1pa0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pa0 RCSB], [https://www.ebi.ac.uk/pdbsum/1pa0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pa0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA2H_BOTPA PA2H_BOTPA] Snake venom phospholipase A2 (PLA2) that lacks enzymatic activity. Is myotoxic. Displays bactericidal activity and promotes the blockage of the neuromuscular contraction of the chick biventer cervicis muscle. Also disrupts artificial membranes, and provokes tissue damages characterized by edema, necrosis and inflammation. May act as pro-inflammatory mediators, inducing metalloproteinase and cytokine production from the inflammatory and satellite cells.<ref>PMID:10860537</ref> <ref>PMID:9972319</ref> <ref>PMID:14623331</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pa/1pa0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pa0 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF BNSP-7, A LYS49-PHOSPHOLIPASE A2===
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==See Also==
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*[[Phospholipase A2 homolog|Phospholipase A2 homolog]]
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{{ABSTRACT_PUBMED_14623331}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1pa0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothropoides_pauloensis Bothropoides pauloensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PA0 OCA].
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</StructureSection>
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[[Category: Bothrops pauloensis]]
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==Reference==
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[[Category: Large Structures]]
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<ref group="xtra">PMID:014623331</ref><references group="xtra"/>
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[[Category: Fontes MR]]
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[[Category: Bothropoides pauloensis]]
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[[Category: Giglio JR]]
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[[Category: Fontes, M R.]]
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[[Category: Magro AJ]]
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[[Category: Giglio, J R.]]
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[[Category: Soares AM]]
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[[Category: Magro, A J.]]
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[[Category: Soares, A M.]]
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[[Category: Bothropic venom]]
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[[Category: Hydrolase]]
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[[Category: Lys49-phospholipase a2]]
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[[Category: Myotoxin]]
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Current revision

CRYSTAL STRUCTURE OF BNSP-7, A LYS49-PHOSPHOLIPASE A2

PDB ID 1pa0

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