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1pl7

From Proteopedia

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[[Image:1pl7.png|left|200px]]
 
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{{STRUCTURE_1pl7| PDB=1pl7 | SCENE= }}
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==Human Sorbitol Dehydrogenase (apo)==
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<StructureSection load='1pl7' size='340' side='right'caption='[[1pl7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Human Sorbitol Dehydrogenase (apo)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1pl7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PL7 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12962626}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pl7 OCA], [https://pdbe.org/1pl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pl7 RCSB], [https://www.ebi.ac.uk/pdbsum/1pl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pl7 ProSAT]</span></td></tr>
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[[1pl7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL7 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/DHSO_HUMAN DHSO_HUMAN] Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity).<ref>PMID:16278369</ref>
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<ref group="xtra">PMID:012962626</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/1pl7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pl7 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: L-iditol 2-dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Adams, P D.]]
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[[Category: Adams PD]]
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[[Category: Beebe, D A.]]
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[[Category: Beebe DA]]
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[[Category: Chrunyk, B.]]
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[[Category: Chrunyk B]]
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[[Category: Cunningham, D.]]
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[[Category: Cunningham D]]
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[[Category: Ekstrom, J L.]]
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[[Category: Ekstrom JL]]
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[[Category: Griffor, M.]]
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[[Category: Griffor M]]
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[[Category: Kamath, A.]]
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[[Category: Kamath A]]
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[[Category: Lee, S E.]]
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[[Category: Lee SE]]
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[[Category: Madura, R.]]
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[[Category: Madura R]]
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[[Category: Mcguire, D.]]
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[[Category: Mcguire D]]
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[[Category: Mylari, B L.]]
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[[Category: Mylari BL]]
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[[Category: Oates, P J.]]
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[[Category: Oates PJ]]
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[[Category: Pauly, T A.]]
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[[Category: Pauly TA]]
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[[Category: Rath, V L.]]
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[[Category: Rath VL]]
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[[Category: Subashi, T.]]
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[[Category: Subashi T]]
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[[Category: Wasilko, D.]]
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[[Category: Wasilko D]]
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[[Category: Watts, P.]]
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[[Category: Watts P]]
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[[Category: Human sorbitol dehydrogenase]]
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[[Category: Oxidoreductase]]
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Current revision

Human Sorbitol Dehydrogenase (apo)

PDB ID 1pl7

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