1p3w

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[[Image:1p3w.png|left|200px]]
 
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{{STRUCTURE_1p3w| PDB=1p3w | SCENE= }}
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==X-ray crystal structure of E. coli IscS==
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<StructureSection load='1p3w' size='340' side='right'caption='[[1p3w]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1p3w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P3W FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p3w OCA], [https://pdbe.org/1p3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p3w RCSB], [https://www.ebi.ac.uk/pdbsum/1p3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p3w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ISCS_ECOLI ISCS_ECOLI] Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Preferentially binds to disordered IscU on which the Fe-S is assembled, IscU converts to the structured state and then dissociates from IscS to transfer the Fe-S to an acceptor protein. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. Transfers sulfur onto 'Cys-456' of ThiI and onto 'Cys-19' of TusA in transpersulfidation reactions.<ref>PMID:8663056</ref> <ref>PMID:10829016</ref> <ref>PMID:11577100</ref> <ref>PMID:16387657</ref> <ref>PMID:22203963</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p3/1p3w_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p3w ConSurf].
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<div style="clear:both"></div>
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===X-ray crystal structure of E. coli IscS===
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==See Also==
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*[[Cysteine desulfurase 3D structures|Cysteine desulfurase 3D structures]]
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{{ABSTRACT_PUBMED_12860127}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1p3w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P3W OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:012860127</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Cupp-Vickery, J R.]]
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[[Category: Large Structures]]
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[[Category: Urbina, H.]]
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[[Category: Cupp-Vickery JR]]
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[[Category: Vickery, L E.]]
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[[Category: Urbina H]]
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[[Category: Csdb]]
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[[Category: Vickery LE]]
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[[Category: Iron sulfur cluster]]
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[[Category: Lyase]]
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[[Category: Nif]]
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Current revision

X-ray crystal structure of E. coli IscS

PDB ID 1p3w

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