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1pl6
From Proteopedia
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| - | [[Image:1pl6.png|left|200px]] | ||
| - | + | ==Human SDH/NADH/inhibitor complex== | |
| - | + | <StructureSection load='1pl6' size='340' side='right'caption='[[1pl6]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1pl6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PL6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=572:4-[2-(HYDROXYMETHYL)PYRIMIDIN-4-YL]-N,N-DIMETHYLPIPERAZINE-1-SULFONAMIDE'>572</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pl6 OCA], [https://pdbe.org/1pl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pl6 RCSB], [https://www.ebi.ac.uk/pdbsum/1pl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pl6 ProSAT]</span></td></tr> |
| - | [[1pl6]] is a 4 chain structure with sequence from [ | + | </table> |
| - | + | == Function == | |
| - | == | + | [https://www.uniprot.org/uniprot/DHSO_HUMAN DHSO_HUMAN] Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity).<ref>PMID:16278369</ref> |
| - | < | + | == Evolutionary Conservation == |
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/1pl6_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pl6 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Adams | + | [[Category: Adams PD]] |
| - | [[Category: Beebe | + | [[Category: Beebe DA]] |
| - | [[Category: Chrunyk | + | [[Category: Chrunyk B]] |
| - | [[Category: Cunningham | + | [[Category: Cunningham D]] |
| - | [[Category: Ekstrom | + | [[Category: Ekstrom JL]] |
| - | [[Category: Griffor | + | [[Category: Griffor M]] |
| - | [[Category: Kamath | + | [[Category: Kamath A]] |
| - | [[Category: Lee | + | [[Category: Lee SE]] |
| - | [[Category: Madura | + | [[Category: Madura R]] |
| - | [[Category: Mcguire | + | [[Category: Mcguire D]] |
| - | [[Category: Mylari | + | [[Category: Mylari BL]] |
| - | [[Category: Oates | + | [[Category: Oates PJ]] |
| - | [[Category: Pauly | + | [[Category: Pauly TA]] |
| - | [[Category: Rath | + | [[Category: Rath VL]] |
| - | [[Category: Subashi | + | [[Category: Subashi T]] |
| - | [[Category: Wasilko | + | [[Category: Wasilko D]] |
| - | [[Category: Watts | + | [[Category: Watts P]] |
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Current revision
Human SDH/NADH/inhibitor complex
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Categories: Homo sapiens | Large Structures | Adams PD | Beebe DA | Chrunyk B | Cunningham D | Ekstrom JL | Griffor M | Kamath A | Lee SE | Madura R | Mcguire D | Mylari BL | Oates PJ | Pauly TA | Rath VL | Subashi T | Wasilko D | Watts P
